Prostaglandin D2 receptor 2

Function

Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.

Classification

Family (Pfam)

PF00001 7tm_1

InterPro

Formyl_rcpt-rel, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM

Functional cluster

G Protein-Coupled Receptors

Experimental structures · PDB · 6

• 6D26 X-ray 2.80A
• 6D27 X-ray 2.74A
• 7M8W X-ray 2.61A
• 8XXU EM 2.54A
• 8XXV EM 2.33A
• 9IYB EM 2.82A

A predicted model is available from AlphaFold.

Gene Ontology · 13

• GO:0043005 neuron projection
• GO:0005886 plasma membrane
• GO:0004930 G protein-coupled receptor activity
• GO:0042923 neuropeptide binding
• GO:0004956 prostaglandin D receptor activity
• GO:0004958 prostaglandin F receptor activity
• GO:0001785 prostaglandin J receptor activity
• GO:0019722 calcium-mediated signaling
• GO:0071799 cellular response to prostaglandin D stimulus
• GO:0006935 chemotaxis
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0006955 immune response
• GO:0007218 neuropeptide signaling pathway

Drugs targeting this protein · 13

• DONITRIPTAN antagonist
• AZD1981 antagonist
• VIDUPIPRANT antagonist
• AM-211 antagonist
• SETIPIPRANT antagonist
• QAV680 antagonist
• FEVIPIPRANT antagonist
• RAMATROBAN antagonist
• AM-461 antagonist
• ARRY-502 antagonist
• BI-671800 antagonist
• TIMAPIPRANT antagonist
• MK-7246 antagonist

Related proteins · sequence + function similarity

• Prostaglandin D2 receptor 2 0.98
• Prostaglandin D2 receptor 2 0.98
• C5a anaphylatoxin chemotactic receptor 2 0.91
• C5a anaphylatoxin chemotactic receptor 1 0.91
• Putative G protein-coupled receptor GPR32P1 0.90
• Probable G protein-coupled receptor 32 0.90
• C5a anaphylatoxin chemotactic receptor 1 0.90
• C5a anaphylatoxin chemotactic receptor 1 0.90
• C-X-C chemokine receptor GPR25 0.90
• C5a anaphylatoxin chemotactic receptor 1 0.90
• Leukotriene B4 receptor 1 0.89
• C5a anaphylatoxin chemotactic receptor 2 0.89

Co-cited proteins · studied together in the literature

• Probable G protein-coupled receptor 45 1 shared papers
• Probable G protein-coupled receptor 34 1 shared papers

Literature · 11 cited papers

• Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: identification of a recycling motif. Eur. J. Pharmacol. · 2010
• Differential regulation of the signaling and trafficking of the two prostaglandin D2 receptors, prostanoid DP receptor and CRTH2. Eur. J. Pharmacol. · 2007
• Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D(2). Biochem. Pharmacol. · 2007
• Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. Br. J. Pharmacol. · 2002
• Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. Blood · 2001
• Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J. Exp. Med. · 2001
• A novel surface molecule of Th2- and Tc2-type cells, CRTH2 expression on human peripheral and decidual CD4+ and CD8+ T cells during the early stage of pregnancy. Clin. Exp. Immunol. · 2001
• Discovery of three novel orphan G-protein-coupled receptors. Genomics · 1999
• Selective expression of a novel surface molecule by human Th2 cells in vivo. J. Immunol. · 1999