NADPH oxidase 1

Function

NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor.

Classification

Family (Pfam)

PF08022 FAD_binding_8, PF01794 Ferric_reduct, PF08030 NAD_binding_6

InterPro

Cyt_b245_heavy_chain, FAD-bd_8, FAD-bd_FR_type, Fe3_Rdtase_TM_dom, Fe_red_NAD-bd_6, FNR_nucleotide-bd, RBOH/FRE, Riboflavin_synthase-like_b-brl

Functional cluster

Mixed Regulatory & Membrane Proteins

Gene Ontology · 24

• GO:0042995 cell projection
• GO:0005769 early endosome
• GO:0043020 NADPH oxidase complex
• GO:0005886 plasma membrane
• GO:0046872 metal ion binding
• GO:0016174 NAD(P)H oxidase H2O2-forming activity
• GO:0050661 NADP binding
• GO:0031267 small GTPase binding
• GO:0016175 superoxide-generating NAD(P)H oxidase activity
• GO:0106292 superoxide-generating NADPH oxidase activity
• GO:0001525 angiogenesis
• GO:0016477 cell migration
• GO:0006952 defense response
• GO:0042743 hydrogen peroxide metabolic process
• GO:0006954 inflammatory response
• GO:0006739 NADP+ metabolic process
• GO:0008284 positive regulation of cell population proliferation
• GO:0045726 positive regulation of integrin biosynthetic process
• GO:0048661 positive regulation of smooth muscle cell proliferation
• GO:0010575 positive regulation of vascular endothelial growth factor production
• GO:0008217 regulation of blood pressure
• GO:0045730 respiratory burst
• GO:0007165 signal transduction
• GO:0042554 superoxide anion generation

Drugs targeting this protein · 1

• SETANAXIB inhibitor

Related proteins · sequence + function similarity

• NADPH oxidase 1 0.96
• NADPH oxidase 1 0.91
• NADPH oxidase 2 0.87
• NADPH oxidase 2 0.87
• NADPH oxidase 2 0.86
• NADPH oxidase 2 0.86
• NADPH oxidase 2 0.86
• Metalloreductase STEAP2 0.71
• Metalloreductase STEAP2 0.71
• Monocyte to macrophage differentiation factor 0.66
• Monocyte to macrophage differentiation factor 0.66
• Monocyte to macrophage differentiation factor 0.66

Co-cited proteins · studied together in the literature

• NADPH oxidase 1 1 shared papers
• NADPH oxidase activator 1 4 shared papers
• NADPH oxidase organizer 1 3 shared papers
• Dual oxidase 2 1 shared papers
• SH3 and PX domain-containing protein 2B 1 shared papers
• Rho guanine nucleotide exchange factor 7 1 shared papers
• SH3 and PX domain-containing protein 2B 1 shared papers
• SH3 and PX domain-containing protein 2A 1 shared papers

Literature · 11 cited papers

• Defects in NADPH oxidase genes NOX1 and DUOX2 in very early onset inflammatory bowel disease. Cell. Mol. Gastroenterol. Hepatol. · 2015
• N-Linked glycosylation of the superoxide-producing NADPH oxidase Nox1. Biochem. Biophys. Res. Commun. · 2014
• Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. Sci. Signal. · 2009
• Nox1-dependent reactive oxygen generation is regulated by Rac1. J. Biol. Chem. · 2006
• Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1. Biochem. Biophys. Res. Commun. · 2006
• The DNA sequence of the human X chromosome. Nature · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain. J. Biol. Chem. · 2004
• A mammalian H+ channel, generated through alternative splicing of the NADPH oxidase homolog NOH-1. Science · 2000
• Cell transformation by the superoxide-generating oxidase Mox1. Nature · 1999