Cysteinyl leukotriene receptor 1
Also known as: CYSLT1, CYSLTR1
Function
Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- CLT1_recept, Cyst_leuk_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM
- Functional cluster
- G Protein-Coupled Receptors
Experimental structures · PDB · 2
A predicted model is available from AlphaFold.
Gene Ontology · 9
- GO:0016020 membrane
- GO:0005886 plasma membrane
- GO:0001631 cysteinyl leukotriene receptor activity
- GO:0004966 galanin receptor activity
- GO:0004974 leukotriene receptor activity
- GO:0006952 defense response
- GO:0007218 neuropeptide signaling pathway
- GO:0007204 positive regulation of cytosolic calcium ion concentration
- GO:0007585 respiratory gaseous exchange by respiratory system
Drugs targeting this protein · 4
- MONTELUKAST SODIUM antagonist
- PRANLUKAST antagonist
- CR-3465 antagonist
- ZAFIRLUKAST antagonist
Related proteins · sequence + function similarity
- Cysteinyl leukotriene receptor 1 1.00
- Cysteinyl leukotriene receptor 1 0.99
- Cysteinyl leukotriene receptor 1 0.99
- Cysteinyl leukotriene receptor 1 0.99
- G protein-coupled receptor 183-A 0.96
- G protein-coupled receptor 183 0.96
- G protein-coupled receptor 183 0.96
- G protein-coupled receptor 183 0.96
- G protein-coupled receptor 183 0.96
- G protein-coupled receptor 183 0.96
- Lysophosphatidic acid receptor 6 0.95
- Lysophosphatidic acid receptor 6 0.95
Literature · 5 cited papers
- The DNA sequence of the human X chromosome. Nature · 2005
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. Mol. Pharmacol. · 1999
- Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature · 1999
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