Aurora kinase C

UniProt Q9UQB9 Organism Homo sapiens Gene AIE2, AIK3, AIRK3, ARK3, AURKC, STK13 EC 2.7.11.1

Also known as: AIE2, AIK3, AIRK3, ARK3, AURKC, STK13

Function

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.

Classification

Family (Pfam): PF00069 Pkinase
InterPro: Aur-like, Kinase-like_dom_sf, Prot_kinase_dom, Protein_kinase_ATP_BS, Ser/Thr_kinase_AS
Functional cluster: Serine/Threonine Protein Kinases

Experimental structures · PDB · 3

6GR8 X-ray 1.75A
6GR9 X-ray 2.25A
9ESA X-ray 2.80A

A predicted model is available from AlphaFold.

Gene Ontology · 23

Disease associations

spermatogenic failure 5 MONDO:0009461

Drugs targeting this protein · 9

GSK-1070916 inhibitor
CENISERTIB inhibitor
ILORASERTIB inhibitor
AMG-900 inhibitor
MK-6592 inhibitor
DANUSERTIB inhibitor
SNS-314 inhibitor
CYC-116 inhibitor
TOZASERTIB inhibitor

Related proteins · sequence + function similarity

Aurora kinase B 0.96
Aurora kinase B 0.95
Aurora kinase B 0.95
Aurora kinase C 0.94
Serine/threonine-protein kinase Aurora-2 0.93
Aurora kinase B 0.92
Aurora kinase B 0.92
Serine/threonine-protein kinase Aurora-1 0.91
Aurora kinase B 0.91
Aurora kinase B 0.90
Aurora kinase B 0.90
Aurora kinase B-A 0.89

Co-cited proteins · studied together in the literature

Aurora kinase C 1 shared papers
Inner centromere protein 2 shared papers
Transforming acidic coiled-coil-containing protein 1 1 shared papers
Baculoviral IAP repeat-containing protein 5 1 shared papers
Aurora kinase B 1 shared papers

Literature · 15 cited papers

Aurora-C interactions with survivin and INCENP reveal shared and distinct features compared with Aurora-B chromosome passenger protein complex. PLoS ONE · 2016
A new AURKC mutation causing macrozoospermia: implications for human spermatogenesis and clinical diagnosis. Mol. Hum. Reprod. · 2011
Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein. Biochem. Biophys. Res. Commun. · 2011
A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development. Hum. Reprod. · 2011
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility. Nat. Genet. · 2007
Patterns of somatic mutation in human cancer genomes. Nature · 2007
Aurora C is directly associated with Survivin and required for cytokinesis. Genes Cells · 2005
Cloning and characterization of a novel human Aurora C splicing variant. Biochem. Biophys. Res. Commun. · 2005
Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. Cell Motil. Cytoskeleton · 2004
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C. J. Biol. Chem. · 2004
The DNA sequence and biology of human chromosome 19. Nature · 2004
… and 3 more in the literature graph

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