Aspartyl aminopeptidase

Function

Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism.

Classification

Family (Pfam)

PF02127 Peptidase_M18

InterPro

Peptidase_M18, Peptidase_M18_dom2

Functional cluster

Zinc-Finger & Ubiquitination Proteins

Experimental structures · PDB · 1

• 4DYO X-ray 2.20A

A predicted model is available from AlphaFold.

Gene Ontology · 10

• GO:0072562 blood microparticle
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005634 nucleus
• GO:0004177 aminopeptidase activity
• GO:0042802 identical protein binding
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding
• GO:0006518 peptide metabolic process
• GO:0006508 proteolysis

Drugs targeting this protein · 1

• TOSEDOSTAT inhibitor

Related proteins · sequence + function similarity

• Aspartyl aminopeptidase 1.00
• Aspartyl aminopeptidase 0.98
• Aspartyl aminopeptidase 0.98
• Aspartyl aminopeptidase 1 0.86
• Aspartyl aminopeptidase 0.81
• Aspartyl aminopeptidase 0.79
• Probable aspartyl aminopeptidase 0.78
• Probable M18 family aminopeptidase 2 0.76
• Aspartyl aminopeptidase 4 0.75
• Vacuolar aminopeptidase 1 0.75
• Probable M18 family aminopeptidase 2 0.75
• Probable M18 family aminopeptidase 2 0.74

Co-cited proteins · studied together in the literature

• Aspartyl aminopeptidase 1 shared papers

Literature · 8 cited papers

• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
• Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family. BMC Struct. Biol. · 2012
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase. J. Biol. Chem. · 1998