Androgen receptor
Also known as: AR, NR3C4
Function
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Classification
- Family (Pfam)
- PF02166 Androgen_recep, PF00104 Hormone_recep, PF00105 zf-C4
- InterPro
- Andrgn_rcpt, NHR-like_dom_sf, Nucl_hrmn_rcpt_lig-bd, Nuclear_hormone_rcpt_NR3, Znf_hrmn_rcpt, Znf_NHR/GATA
- Functional cluster
- Homeobox & Zinc-Finger Transcription Factors
Gene Ontology · 22
- GO:0000785 chromatin
- GO:0005737 cytoplasm
- GO:0005634 nucleus
- GO:0005497 androgen binding
- GO:0008013 beta-catenin binding
- GO:0003700 DNA-binding transcription factor activity
- GO:0034056 estrogen response element binding
- GO:0004879 nuclear receptor activity
- GO:0005496 steroid binding
- GO:0000976 transcription cis-regulatory region binding
- GO:0008270 zinc ion binding
- GO:0030521 androgen receptor signaling pathway
- GO:0006351 DNA-templated transcription
- GO:0030522 intracellular receptor signaling pathway
- GO:0008584 male gonad development
- GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
- GO:0008284 positive regulation of cell population proliferation
- GO:0010628 positive regulation of gene expression
- GO:0045944 positive regulation of transcription by RNA polymerase II
- GO:1903076 regulation of protein localization to plasma membrane
- GO:0033574 response to testosterone
- GO:0007283 spermatogenesis
Drugs targeting this protein · 1
- OSATERONE ACETATE antagonist
Related proteins · sequence + function similarity
- Androgen receptor 0.98
- Androgen receptor 0.98
- Androgen receptor 0.98
- Androgen receptor 0.98
- Androgen receptor 0.98
- Androgen receptor 0.98
- Androgen receptor 0.98
- Androgen receptor 0.98
- Androgen receptor 0.97
- Androgen receptor 0.96
- Androgen receptor 0.94
- Progesterone receptor 0.86
Literature · 1 cited papers
- Molecular cloning and functional characterization of the canine androgen receptor. Mol. Cell. Biochem. · 2001
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