Polymerase acidic protein
Also known as: PA
Function
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
Classification
- Family (Pfam)
- PF00603 Flu_PA
- InterPro
- INFV_PA, PA/PA-X, PA/PA-X_sf
- Functional cluster
- Viral Structural & Replication Proteins
Gene Ontology · 12
- GO:0030430 host cell cytoplasm
- GO:0042025 host cell nucleus
- GO:0004519 endonuclease activity
- GO:0016787 hydrolase activity
- GO:0046872 metal ion binding
- GO:0003723 RNA binding
- GO:0075526 cap snatching
- GO:0006351 DNA-templated transcription
- GO:0039657 symbiont-mediated suppression of host gene expression
- GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
- GO:0039694 viral RNA genome replication
- GO:0075523 viral translational frameshifting
Drugs targeting this protein · 2
- BALOXAVIR inhibitor
- BALOXAVIR MARBOXIL inhibitor
Related proteins · sequence + function similarity
- Polymerase acidic protein 0.99
- Polymerase acidic protein 0.99
- Polymerase acidic protein 0.99
- Polymerase acidic protein 0.98
- Polymerase basic protein 2 0.84
- Polymerase basic protein 2 0.84
- Polymerase basic protein 2 0.84
- Outer capsid protein VP2 0.81
- Polymerase basic protein 2 0.81
- Polymerase acidic protein 0.81
- Polymerase acidic protein 0.80
- Polymerase acidic protein 0.80
Co-cited proteins · studied together in the literature
- Polymerase basic protein 2 1 shared papers
Literature · 1 cited papers
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