Potassium voltage-gated channel subfamily KQT member 5
Also known as: KCNQ5
Function
Pore-forming subunit of the voltage-gated potassium (Kv) channel broadly expressed in brain and involved in the regulation of neuronal excitability. Associates with KCNQ3/Kv7.3 pore-forming subunit to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Contributes, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Also forms a functional channel with KCNQ1/Kv7.1 subunit that may contribute to vasoconstriction and hypertension. Channel may be selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) = Rb(+) > Cs(+) > Na(+). Similar to the native M-channel, KCNQ3-KCNQ5 potassium channel is suppressed by activation of the muscarinic acetylcholine receptor CHRM1.
Classification
- Family (Pfam)
- PF00520 Ion_trans, PF03520 KCNQ_channel
- InterPro
- Ion_trans_dom, K_chnl_volt-dep_KCNQ, K_chnl_volt-dep_KCNQ_C
- Functional cluster
- Homeobox & Zinc-Finger Transcription Factors
Experimental structures · PDB · 5
A predicted model is available from AlphaFold.
Gene Ontology · 5
Disease associations
- intellectual disability, autosomal dominant 46 MONDO:0030911
Drugs targeting this protein · 8
- TEDISAMIL blocker
- GUANIDINE HYDROCHLORIDE blocker
- NERISPIRDINE blocker
- FLINDOKALNER activator
- DALFAMPRIDINE blocker
- AMIFAMPRIDINE PHOSPHATE blocker
- AMIFAMPRIDINE blocker
- EZOGABINE opener
Related proteins · sequence + function similarity
- Potassium voltage-gated channel subfamily KQT member 5 0.99
- Potassium voltage-gated channel subfamily KQT member 2 0.89
- Potassium voltage-gated channel subfamily KQT member 2 0.85
- Potassium voltage-gated channel subfamily KQT member 4 0.83
- Potassium voltage-gated channel subfamily KQT member 3 0.83
- Potassium voltage-gated channel subfamily KQT member 1 0.81
- Potassium voltage-gated channel subfamily KQT member 3 0.81
- Potassium voltage-gated channel subfamily KQT member 3 0.81
- Potassium voltage-gated channel subfamily KQT member 1 0.81
- Potassium voltage-gated channel subfamily KQT member 3 0.81
- Potassium voltage-gated channel subfamily KQT member 2 0.81
- Potassium voltage-gated channel subfamily KQT member 4 0.80
Co-cited proteins · studied together in the literature
- Potassium voltage-gated channel subfamily KQT member 4 1 shared papers
- Synaptophysin 1 shared papers
- Potassium voltage-gated channel subfamily KQT member 3 1 shared papers
- Potassium voltage-gated channel subfamily KQT member 1 1 shared papers
Literature · 11 cited papers
- A calmodulin C-lobe Ca(2+)-dependent switch governs Kv7 channel function. Neuron · 2018
- Loss-of-function and gain-of-function mutations in KCNQ5 cause intellectual disability or epileptic encephalopathy. Am. J. Hum. Genet. · 2017
- Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology. Arterioscler. Thromb. Vasc. Biol. · 2014
- Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
- The consensus coding sequences of human breast and colorectal cancers. Science · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- The DNA sequence and analysis of human chromosome 6. Nature · 2003
- Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells. Br. J. Pharmacol. · 2001
- KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents. J. Biol. Chem. · 2000
- Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity. J. Biol. Chem. · 2000