Xaa-Pro aminopeptidase 3

Function

Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at the P1 position.

Classification

Family (Pfam)

PF05195 AMP_N, PF00557 Peptidase_M24

InterPro

Aminopep_P_N, Creatin/AminoP/Spt16_N, Creatinase/aminopeptidase-like, Pept_M24, X-Pro_dipept-like

Functional cluster

Zinc-Finger & Ubiquitination Proteins

Experimental structures · PDB · 1

• 5X49 X-ray 1.65A

A predicted model is available from AlphaFold.

Gene Ontology · 10

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005739 mitochondrion
• GO:0004177 aminopeptidase activity
• GO:0030145 manganese ion binding
• GO:0070006 metalloaminopeptidase activity
• GO:0042803 protein homodimerization activity
• GO:0003094 glomerular filtration
• GO:0016485 protein processing
• GO:0006508 proteolysis

Disease associations

• nephronophthisis-like nephropathy 1 MONDO:0013163

Drugs targeting this protein · 1

• TOSEDOSTAT inhibitor

Related proteins · sequence + function similarity

• Xaa-Pro aminopeptidase 3 1.00
• Xaa-Pro aminopeptidase 3 0.98
• Xaa-Pro aminopeptidase 3 0.97
• Intermediate cleaving peptidase 55, mitochondrial 0.70
• Probable Xaa-Pro aminopeptidase PEPP 0.66
• Intermediate cleaving peptidase 55 0.66
• Probable Xaa-Pro aminopeptidase PEPP 0.66
• Probable Xaa-Pro aminopeptidase PEPP 0.65
• Probable Xaa-Pro aminopeptidase PAAG_05466 0.65
• Intermediate cleaving peptidase 55 0.64
• Probable Xaa-Pro aminopeptidase PEPP 0.63
• Probable Xaa-Pro aminopeptidase NFIA_010500 0.62

Co-cited proteins · studied together in the literature

• Xaa-Pro aminopeptidase 3 1 shared papers
• Xaa-Pro aminopeptidase 3 1 shared papers
• Tumor necrosis factor receptor superfamily member 1B 1 shared papers
• TNF receptor-associated factor 2 1 shared papers

Literature · 11 cited papers

• Structure of the human aminopeptidase XPNPEP3 and comparison of its in vitro activity with Icp55 orthologs: Insights into diverse cellular processes. J. Biol. Chem. · 2017
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2. J. Cell Sci. · 2015
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. J. Clin. Invest. · 2010
• The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
• Aminopeptidase P isozyme expression in human tissues and peripheral blood mononuclear cell fractions. Arch. Biochem. Biophys. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• The DNA sequence of human chromosome 22. Nature · 1999