Large ribosomal subunit protein uL3

UniProt Q9HWD5 Organism Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Gene PA4263, rplC

Also known as: PA4263, rplC

Function

One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.

Classification

Family (Pfam): PF00297 Ribosomal_L3
InterPro: Ribosomal_uL3, Ribosomal_uL3_bact_org, Ribosomal_uL3_CS, Transl_B-barrel_sf
Functional cluster: Large Ribosomal Subunit Proteins

Experimental structures · PDB · 6

7UNR EM 2.90A
7UNU EM 2.90A
7UNV EM 2.70A
7UNW EM 2.60A
8CD1 EM 3.00A
8RWG EM 2.46A

A predicted model is available from AlphaFold.

Gene Ontology · 4

Drugs targeting this protein · 2

TOBRAMYCIN inhibitor
TOBRAMYCIN SULFATE inhibitor

Related proteins · sequence + function similarity

Literature · 1 cited papers

Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature · 2000

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