lmmol · Proteins

Histamine H4 receptor

UniProt Q9H3N8 Organism Homo sapiens Gene GPCR105, HRH4

Also known as: GPCR105, HRH4

Function

G protein-coupled receptor primarily expressed in immune cells such as mast cells, eosinophils, basophils, dendritic cells and neutrophils that plays a key role in immune and inflammatory responses. Mediates chemotaxis of immune cells to sites of inflammation or injury by responding to histamine. Activation by histamine also influences the release of proinflammatory cytokines such as TNF, CCL4, IL6 and IFN-gamma. Ligand binding induces a conformation change that triggers signaling via G(i)/GNAI1 leading to decreased intracellular cAMP levels by inhibiting adenylate cyclase activity. In addition, plays a role in the control of renal reabsorption processes, particularly albumin uptake (By similarity).

Classification

Family (Pfam)
PF00001 7tm_1
InterPro
GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Histamine_H4_rcpt
Functional cluster
Membrane Transporters & GPCRs

Experimental structures · PDB · 15

A predicted model is available from AlphaFold.

Gene Ontology · 12

Drugs targeting this protein · 3

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 14 cited papers

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