S-methylmethionine--homocysteine S-methyltransferase BHMT2

Function

Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor.

Classification

Family (Pfam)

PF02574 S-methyl_trans

InterPro

BHMT, BHMT-like, HCY_dom, HCY_dom_sf

Functional cluster

Amino-Acid & Central Metabolism Enzymes

Gene Ontology · 8

• GO:0005829 cytosol
• GO:0070062 extracellular exosome
• GO:0061627 S-methylmethionine-homocysteine S-methyltransferase activity
• GO:0008270 zinc ion binding
• GO:0071267 L-methionine salvage
• GO:0032259 methylation
• GO:0046500 S-adenosylmethionine metabolic process
• GO:0033477 S-methylmethionine metabolic process

Drugs targeting this protein · 1

• BETAINE substrate

Related proteins · sequence + function similarity

• S-methylmethionine--homocysteine S-methyltransferase BHMT2 1.00
• S-methylmethionine--homocysteine S-methyltransferase BHMT2 0.96
• S-methylmethionine--homocysteine S-methyltransferase BHMT2 0.95
• Betaine--homocysteine S-methyltransferase 1 0.87
• Betaine--homocysteine S-methyltransferase 1 0.86
• Betaine--homocysteine S-methyltransferase 1 0.86
• Betaine--homocysteine S-methyltransferase 1 0.85
• Betaine--homocysteine S-methyltransferase 1 0.85
• Betaine--homocysteine S-methyltransferase 1 0.84
• Betaine--homocysteine S-methyltransferase 1 0.83
• Betaine--homocysteine S-methyltransferase 1 0.83
• Betaine--homocysteine S-methyltransferase 1 0.83

Co-cited proteins · studied together in the literature

• S-methylmethionine--homocysteine S-methyltransferase BHMT2 2 shared papers

Literature · 6 cited papers

• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase. J. Biol. Chem. · 2008
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The DNA sequence and comparative analysis of human chromosome 5. Nature · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes. Genomics · 2000