Tubulin beta chain

Function

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

Classification

Family (Pfam)

PF00091 Tubulin, PF03953 Tubulin_C

InterPro

Beta-tubulin_BS, Beta_tubulin, Tub_FtsZ_C, Tubulin, Tubulin/FtsZ-like_C, Tubulin/FtsZ_2-layer-sand-dom, Tubulin/FtsZ_GTPase_sf, Tubulin_C, Tubulin_CS, Tubulin_FtsZ_GTPase

Functional cluster

Tubulins & Mitochondrial Metabolic Enzymes

Gene Ontology · 8

• GO:0005874 microtubule
• GO:0005525 GTP binding
• GO:0003924 GTPase activity
• GO:0046872 metal ion binding
• GO:0005200 structural constituent of cytoskeleton
• GO:0000070 mitotic sister chromatid segregation
• GO:0007052 mitotic spindle organization
• GO:0097435 supramolecular fiber organization

Drugs targeting this protein · 1

• FENBENDAZOLE binding agent

Related proteins · sequence + function similarity

• Tubulin beta chain 1.00
• Tubulin beta chain 1.00
• Tubulin beta chain 0.98
• Tubulin beta-2 chain 0.98
• Tubulin beta-1 chain 0.98
• Tubulin beta-5 chain 0.98
• Tubulin beta-7 chain 0.98
• Tubulin beta chain, nucleomorph 0.98
• Tubulin beta-1 chain 0.98
• Tubulin beta chain 0.98
• Tubulin beta chain 0.98
• Tubulin beta-1 chain 0.98