MAP kinase-interacting serine/threonine-protein kinase 1

Function

May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.

Classification

Family (Pfam)

PF00069 Pkinase

InterPro

CDPK_Ser/Thr_kinases, Kinase-like_dom_sf, Prot_kinase_dom, Protein_kinase_ATP_BS, Ser/Thr_kinase_AS

Functional cluster

Eukaryotic Transcription Factors & related

Experimental structures · PDB · 3

• 2HW6 X-ray 2.50A
• 2Y9Q X-ray 1.55A
• 5WVD X-ray 3.00A

A predicted model is available from AlphaFold.

Gene Ontology · 14

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0005524 ATP binding
• GO:0009931 calcium-dependent protein serine/threonine kinase activity
• GO:0004683 calcium/calmodulin-dependent protein kinase activity
• GO:0005516 calmodulin binding
• GO:0046872 metal ion binding
• GO:0106310 protein serine kinase activity
• GO:0004674 protein serine/threonine kinase activity
• GO:0035556 intracellular signal transduction
• GO:0006468 protein phosphorylation
• GO:0006417 regulation of translation

Drugs targeting this protein · 1

• TOMIVOSERTIB inhibitor

Related proteins · sequence + function similarity

• MAP kinase-interacting serine/threonine-protein kinase 1 0.95
• MAP kinase-interacting serine/threonine-protein kinase 1 0.94
• MAP kinase-interacting serine/threonine-protein kinase 2 0.92
• MAP kinase-interacting serine/threonine-protein kinase 2 0.92
• MAP kinase-interacting serine/threonine-protein kinase 2 0.91
• MAP kinase-interacting serine/threonine-protein kinase 1 0.91
• Ribosomal protein S6 kinase alpha-4 0.85
• MAP kinase-interacting serine/threonine-protein kinase 1 0.84
• MAP kinase-interacting serine/threonine-protein kinase 1 0.84
• Ribosomal protein S6 kinase alpha-4 0.84
• MAP kinase-interacting serine/threonine-protein kinase 2 0.83
• MAP kinase-interacting serine/threonine-protein kinase 2 0.81

Co-cited proteins · studied together in the literature

• MAP kinase-interacting serine/threonine-protein kinase 2 1 shared papers
• MAP kinase-interacting serine/threonine-protein kinase 1 1 shared papers
• Mitogen-activated protein kinase 3 1 shared papers
• Eukaryotic translation initiation factor 4 gamma 2 1 shared papers
• Serine/threonine-protein kinase PAK 2 1 shared papers
• Eukaryotic translation initiation factor 4 gamma 1 1 shared papers
• Eukaryotic translation initiation factor 4E 1 shared papers

Literature · 10 cited papers

• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
• Patterns of somatic mutation in human cancer genomes. Nature · 2007
• The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1. Exp. Cell Res. · 2004
• Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. J. Biol. Chem. · 2004
• Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. Mol. Cell. Biol. · 2001
• Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J. · 1999
• MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J. · 1997