Large ribosomal subunit protein uL23

UniProt Q9A1X2 Organism Streptococcus pyogenes serotype M1 Gene M5005_Spy0046, SPy_0051, rplW

Also known as: M5005_Spy0046, SPy_0051, rplW

Function

One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.

Classification

Family (Pfam): PF00276 Ribosomal_L23
InterPro: Nucleotide-bd_a/b_plait_sf, Ribosomal_uL23-like, Ribosomal_uL23/eL15/eS24_sf, Ribosomal_uL23_CS
Functional cluster: Small/Large Ribosomal Subunit Proteins

Gene Ontology · 5

Drugs targeting this protein · 1

RETAPAMULIN inhibitor

Related proteins · sequence + function similarity

Literature · 2 cited papers

Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events. J. Infect. Dis. · 2005
Complete genome sequence of an M1 strain of Streptococcus pyogenes. Proc. Natl. Acad. Sci. U.S.A. · 2001

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