Monoglyceride lipase

UniProt Q99685 Organism Homo sapiens Gene MGLL EC 3.1.1.23

Also known as: MGLL

Function

Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.

Classification

Family (Pfam): PF12146 Hydrolase_4
InterPro: AB_hydrolase_1, AB_hydrolase_fold, Hydrolase_4, MAG_DAG_Lipase
Functional cluster: Cytochrome P450 & Heme Enzymes

Experimental structures · PDB · 29

3HJU X-ray 2.20A
3JW8 X-ray 2.10A
3JWE X-ray 2.70A
3PE6 X-ray 1.35A
4UUQ X-ray 2.36A
5ZUN X-ray 1.35A
6AX1 X-ray 2.26A
6BQ0 X-ray 2.00A
7L4T X-ray 2.20A
7L4U X-ray 2.25A
7L4W X-ray 2.20A
7L50 X-ray 2.30A
… and 17 more

A predicted model is available from AlphaFold.

Gene Ontology · 18

Drugs targeting this protein · 1

ELCUBRAGISTAT inhibitor

Related proteins · sequence + function similarity

Monoglyceride lipase 0.98
Monoglyceride lipase 0.97
Platelet-activating factor acetylhydrolase 2, cytoplasmic 0.58
Platelet-activating factor acetylhydrolase 2, cytoplasmic 0.58
Protein ABHD1 0.58
Platelet-activating factor acetylhydrolase 2, cytoplasmic 0.57
Protein ABHD13 0.57
Monoglyceride lipase homolog 0.57
Protein ABHD1 0.57
sn-1-specific diacylglycerol lipase ABHD11 0.56
Epoxide hydrolase 3 0.56
sn-1-specific diacylglycerol lipase ABHD11 0.56

Co-cited proteins · studied together in the literature

Monoglyceride lipase 2 shared papers
Semaphorin-like protein 139 1 shared papers
Monoacylglycerol lipase ABHD6 1 shared papers
Cocaine esterase 1 shared papers
Lysophosphatidylserine lipase ABHD12 1 shared papers
Fatty-acid amide hydrolase 1 1 shared papers
Liver carboxylesterase 1 1 shared papers

Literature · 15 cited papers

Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency. Mol. Pharmacol. · 2014
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Biochemical and pharmacological characterization of human alpha/beta-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12). J. Lipid Res. · 2012
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2. Chem. Res. Toxicol. · 2010
Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell · 2010
Structural basis for human monoglyceride lipase inhibition. J. Mol. Biol. · 2010
Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling. ChemBioChem · 2010
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat. Chem. Biol. · 2009
The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
The DNA sequence, annotation and analysis of human chromosome 3. Nature · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
… and 3 more in the literature graph

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