Pyruvate dehydrogenase [NADP(+)]
Also known as: PFOR
Function
May have an important role in respiratory metabolism. Cryptosporidium have a relic mitochondrion with no function in energy metabolism so it is not known if PFOR has a function.
Classification
- Family (Pfam)
- PF10371 EKR, PF00667 FAD_binding_1, PF12838 Fer4_7, PF00258 Flavodoxin_1, PF00175 NAD_binding_1, PF17147 PFOR_II, PF01558 POR, PF01855 POR_N, PF02775 TPP_enzyme_C
- InterPro
- 4Fe4S_Fe-S-bd, 4Fe4S_Fe_S_CS, CysJ-like_FAD-binding, FAD-bd_FR_type, Flavdoxin-like, Flavodoxin/NO_synth, Flavoprot_Pyr_Nucl_cyt_Rdtase, Flavoprotein-like_sf, FNR_nucleotide-bd, NADPH_Cyt_P450_Rdtase_alpha, OxRdtase_FAD/NAD-bd, PFOR_II, Pyruvate:ferred/Flavod_OxRd, Pyrv-flavodox_OxR_EKR_sf, Pyrv-flavodox_OxRtase_EKR, Pyrv/ketoisovalerate_OxRed_cat, Pyrv_Fd/Flavodoxin_OxRdtase_N, Pyrv_flavodox_OxRed, Pyrv_flavodox_OxRed_cen, Riboflavin_synthase-like_b-brl, THDP-binding, TPP_enzyme_TPP-bd, Transketo_C/PFOR_II
- Functional cluster
- Oxidoreductases, Catalases & Peroxidases
Gene Ontology · 10
- GO:0005739 mitochondrion
- GO:0051539 4 iron, 4 sulfur cluster binding
- GO:0010181 FMN binding
- GO:0005506 iron ion binding
- GO:0016491 oxidoreductase activity
- GO:0050243 pyruvate dehydrogenase (NADP+) activity
- GO:0030976 thiamine pyrophosphate binding
- GO:0045333 cellular respiration
- GO:0022900 electron transport chain
- GO:0006979 response to oxidative stress
Drugs targeting this protein · 1
- NITAZOXANIDE inhibitor
Related proteins · sequence + function similarity
- Pyruvate:flavodoxin oxidoreductase 0.85
- Pyruvate:flavodoxin oxidoreductase 0.85
- Pyruvate:flavodoxin oxidoreductase 0.84
- Putative pyruvate:flavodoxin oxidoreductase 0.83
- Pyruvate:flavodoxin oxidoreductase 0.83
- Pyruvate dehydrogenase [NADP(+)], mitochondrial 0.82
- Pyruvate:ferredoxin oxidoreductase 0.81
- Pyruvate:ferredoxin oxidoreductase 0.81
- Pyruvate:flavodoxin oxidoreductase 0.81
- Probable phosphoketolase 1 0.78
- Probable phosphoketolase 0.76
- Probable phosphoketolase 0.75
Co-cited proteins · studied together in the literature
- Pyruvate dehydrogenase [NADP(+)], mitochondrial 1 shared papers
Literature · 1 cited papers
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