Potassium voltage-gated channel subfamily B member 2

UniProt Q92953 Organism Homo sapiens Gene KCNB2

Also known as: KCNB2

Function

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells.

Classification

Family (Pfam): PF02214 BTB_2, PF00520 Ion_trans, PF03521 Kv2channel
InterPro: BTB/POZ_dom, Ion_trans_dom, K_chnl_volt-dep_Kv, K_chnl_volt-dep_Kv2, K_chnl_volt-dep_Kv2.2, SKP1/BTB/POZ_sf, T1-type_BTB, VG_K_chnl, Volt_channel_dom_sf
Functional cluster: RNA Polymerase II Transcription Factors

Gene Ontology · 16

Drugs targeting this protein · 6

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Potassium voltage-gated channel subfamily B member 2 2 shared papers
Potassium voltage-gated channel subfamily B member 2 1 shared papers
Potassium voltage-gated channel subfamily B member 2 1 shared papers
Potassium voltage-gated channel subfamily B member 2 1 shared papers
Motile sperm domain-containing protein 2 1 shared papers
Potassium voltage-gated channel subfamily B member 1 1 shared papers
Potassium voltage-gated channel subfamily B member 1 1 shared papers
Potassium voltage-gated channel subfamily B member 1 2 shared papers
Mitoguardin 2 1 shared papers
Potassium voltage-gated channel subfamily B member 2 1 shared papers
Regulator of microtubule dynamics protein 3 1 shared papers
StAR-related lipid transfer protein 3 1 shared papers

Literature · 4 cited papers

FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts. EMBO J. · 2020
The consensus coding sequences of human breast and colorectal cancers. Science · 2006
Molecular diversity of K+ channels. Ann. N. Y. Acad. Sci. · 1999
Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles. Am. J. Physiol. · 1998

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.