Caspase-10

Function

Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.

Classification

Family (Pfam)

PF01335 DED, PF00656 Peptidase_C14

InterPro

CASP10_DED2, Caspase-like_dom_sf, Caspase_cys_AS, Caspase_his_AS, DEATH-like_dom_sf, DED_dom, Pept_C14_caspase, Pept_C14_p10, Pept_C14_p20, Pept_C14A

Functional cluster

Zinc-Finger & Chromatin Regulatory Proteins

Gene Ontology · 13

• GO:0031265 CD95 death-inducing signaling complex
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0097342 ripoptosome
• GO:0004197 cysteine-type endopeptidase activity
• GO:0035877 death effector domain binding
• GO:0031625 ubiquitin protein ligase binding
• GO:0006915 apoptotic process
• GO:0043123 positive regulation of canonical NF-kappaB signal transduction
• GO:1900119 positive regulation of execution phase of apoptosis
• GO:0043525 positive regulation of neuron apoptotic process
• GO:0051604 protein maturation
• GO:0006508 proteolysis

Disease associations

• autoimmune lymphoproliferative syndrome type 2A MONDO:0011383
• lymphoma, non-Hodgkin, familial MONDO:0011508
• gastric cancer MONDO:0001056

Drugs targeting this protein · 1

• EMRICASAN inhibitor

Related proteins · sequence + function similarity

• Caspase-8 0.88
• Caspase-8 0.86
• CASP8 and FADD-like apoptosis regulator 0.84
• Caspase-8 0.83
• Caspase-2 0.81
• Caspase-2 0.81
• Caspase-2 0.79
• CASP8 and FADD-like apoptosis regulator 0.77
• CASP8 and FADD-like apoptosis regulator 0.77
• Caspase-2 0.75
• Caspase-9 0.74
• Caspase-9 0.71

Co-cited proteins · studied together in the literature

• Caspase-8 6 shared papers
• Serine/threonine-protein kinase RIO3 1 shared papers
• E3 ubiquitin-protein ligase RNF34 1 shared papers
• E3 ubiquitin-protein ligase rififylin 1 shared papers
• STE20-related kinase adapter protein beta 1 shared papers
• Trafficking kinesin-binding protein 2 1 shared papers
• NIF3-like protein 1 1 shared papers
• Caspase-7 2 shared papers
• CASP8 and FADD-like apoptosis regulator 1 shared papers
• Interferon regulatory factor 3 1 shared papers
• Caspase-3 1 shared papers
• Caspase-9 1 shared papers

Literature · 22 cited papers

• Analysis of protein-coding genetic variation in 60,706 humans. Nature · 2016
• Atypical presentation of autoimmune lymphoproliferative syndrome due to CASP10 mutation. Immunol. Lett. · 2016
• Mutational analysis of CASP10 gene in colon, breast, lung and hepatocellular carcinomas. Pathology · 2010
• Mutational analysis of CASP10 gene in acute leukaemias and multiple myelomas. Pathology · 2009
• RIOK3 interacts with caspase-10 and negatively regulates the NF-kappaB signaling pathway. Mol. Cell. Biochem. · 2009
• Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma. Hum. Mutat. · 2008
• Cloning and characterization of a novel caspase-10 isoform that activates NF-kappa B activity. Biochim. Biophys. Acta · 2007
• Engineered hybrid dimers: tracking the activation pathway of caspase-7. Mol. Cell · 2006
• Genetic alterations in caspase-10 may be causative or protective in autoimmune lymphoproliferative syndrome. Hum. Genet. · 2006
• Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. Proc. Natl. Acad. Sci. U.S.A. · 2004
• … and 10 more in the literature graph