Carnitine O-palmitoyltransferase 1, muscle isoform

Function

Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion.

Classification

Family (Pfam)

PF00755 Carn_acyltransf, PF16484 CPT_N

InterPro

Carn_acyl_trans, CAT-like_dom_sf, Cho/carn_acyl_trans, Cho/carn_acyl_trans_2, CPT_N

Functional cluster

Zinc-Finger & Ubiquitination Proteins

Gene Ontology · 10

• GO:0005758 mitochondrial intermembrane space
• GO:0005741 mitochondrial outer membrane
• GO:0005739 mitochondrion
• GO:0004095 carnitine O-palmitoyltransferase activity
• GO:0009437 carnitine metabolic process
• GO:0006853 carnitine shuttle
• GO:0006635 fatty acid beta-oxidation
• GO:0006631 fatty acid metabolic process
• GO:0015909 long-chain fatty acid transport
• GO:0009637 response to blue light

Drugs targeting this protein · 1

• PERHEXILINE MALEATE inhibitor

Related proteins · sequence + function similarity

• Carnitine O-palmitoyltransferase 1, muscle isoform 0.98
• Carnitine O-palmitoyltransferase 1, muscle isoform 0.97
• Carnitine O-palmitoyltransferase 1, muscle isoform 0.97
• Carnitine O-palmitoyltransferase 1, muscle isoform 0.97
• Carnitine O-palmitoyltransferase 1, liver isoform 0.95
• Carnitine O-palmitoyltransferase 1, liver isoform 0.95
• Carnitine O-palmitoyltransferase 1, liver isoform 0.94
• Carnitine O-palmitoyltransferase 1, liver isoform 0.94
• Peroxisomal carnitine O-octanoyltransferase 0.88
• Peroxisomal carnitine O-octanoyltransferase 0.88
• Peroxisomal carnitine O-octanoyltransferase 0.86
• Peroxisomal carnitine O-octanoyltransferase 0.86

Co-cited proteins · studied together in the literature

• Coiled-coil domain-containing protein 157 1 shared papers
• RIMS-binding protein 3A 1 shared papers
• Uncharacterized protein KIAA1671 1 shared papers
• Protein shisa-like-1 1 shared papers
• Protein Tob2 1 shared papers
• Guanine nucleotide-binding protein subunit beta-like protein 1 1 shared papers
• EF-hand calcium-binding domain-containing protein 6 1 shared papers
• BLOC-3 complex member HPS4 1 shared papers
• Oxysterol-binding protein 2 1 shared papers
• Ceramide kinase 1 shared papers
• TRIO and F-actin-binding protein 1 shared papers
• Gamma-tubulin complex component 6 1 shared papers

Literature · 8 cited papers

• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. DNA Res. · 2001
• The DNA sequence of human chromosome 22. Nature · 1999
• Functional studies of yeast-expressed human heart muscle carnitine palmitoyltransferase I. Arch. Biochem. Biophys. · 1997
• Structural features of the gene encoding human muscle type carnitine palmitoyltransferase I. FEBS Lett. · 1997
• Localization and intron usage analysis of the human CPT1B gene for muscle type carnitine palmitoyltransferase I. Biochim. Biophys. Acta · 1997
• Fine chromosome mapping of the genes for human liver and muscle carnitine palmitoyltransferase I (CPT1A and CPT1B). Genomics · 1997
• Isolation and characterization of cDNA and genomic clones encoding human muscle type carnitine palmitoyltransferase I. Biochim. Biophys. Acta · 1996