lmmol · Proteins

Transient receptor potential cation channel subfamily V member 1

UniProt Q8NER1 Organism Homo sapiens Gene TRPV1, VR1

Also known as: TRPV1, VR1

Function

Non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activated by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius. Upon activation, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.

Classification

Family (Pfam)
PF00023 Ank, PF12796 Ank_2, PF00520 Ion_trans
InterPro
Ankyrin_rpt, Ankyrin_rpt-contain_sf, Ion_trans_dom, TRPV, TrpV1-4
Functional cluster
Serine/Threonine Protein Kinases

Experimental structures · PDB · 8

A predicted model is available from AlphaFold.

Gene Ontology · 30

Drugs targeting this protein · 13

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 11 cited papers

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.