1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic
Also known as: DXR
Function
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
Classification
- Family (Pfam)
- PF08436 DXP_redisom_C, PF02670 DXP_reductoisom, PF13288 DXPR_C
- InterPro
- DXP_reductoisomerase, DXP_reductoisomerase_C, DXP_reductoisomerase_N, DXPR_C, DXPR_C_sf, NAD(P)-bd_dom_sf
- Functional cluster
- Ribosomal S4 & Metabolic Enzymes
Experimental structures · PDB · 11
- 4Y67 X-ray 1.60A
- 4Y6P X-ray 1.90A
- 4Y6R X-ray 1.90A
- 4Y6S X-ray 2.10A
- 5JAZ X-ray 1.40A
- 5JBI X-ray 1.70A
- 5JC1 X-ray 1.65A
- 5JMP X-ray 1.70A
- 5JMW X-ray 1.55A
- 5JNL X-ray 1.60A
- 5JO0 X-ray 1.80A
A predicted model is available from AlphaFold.
Gene Ontology · 5
Drugs targeting this protein · 1
- FOSMIDOMYCIN inhibitor
Related proteins · sequence + function similarity
- 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.00
- 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, apicoplast 0.72
- 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, apicoplast 0.72
- Bifunctional glucose-6-phosphate 1-dehydrogenase/6-phosphogluconolactonase 0.72
- Exonuclease/flap endonuclease PbExo 0.69
- 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.69
- Apurinic-apyrimidinic endonuclease 1 0.69
- Putative cysteine desulfurase PbSufS 0.69
- Dihydroorotate dehydrogenase (quinone), mitochondrial 0.68
- Bifunctional dihydrofolate reductase-thymidylate synthase 0.68
- Translation factor GUF1 homolog, mitochondrial 0.67
- Cysteine desulfurase SufS 0.67
Literature · 3 cited papers
- Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with beta-Arylpropyl Analogues of Fosmidomycin. ChemMedChem · 2016
- Synthesis and bioactivity of beta-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase. J. Med. Chem. · 2015
- Genome sequence of the human malaria parasite Plasmodium falciparum. Nature · 2002
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