Carbapenem-hydrolyzing beta-lactamase KPC

Function

Hydrolyzes carbapenems, penicillins, cephalosporins and aztreonam with varying efficiency.

Classification

Family (Pfam)

PF13354 Beta-lactamase2

InterPro

Beta-lactam/transpept-like, Beta-lactam_cat, Beta-lactam_class-A, KPC-2/SME-1-like

Functional cluster

Oxidoreductases & Polyketide Synthases

Experimental structures · PDB · 1

• 5MGI X-ray 1.50A

A predicted model is available from AlphaFold.

Gene Ontology · 3

• GO:0008800 beta-lactamase activity
• GO:0030655 beta-lactam antibiotic catabolic process
• GO:0046677 response to antibiotic

Drugs targeting this protein · 1

• RELEBACTAM inhibitor

Related proteins · sequence + function similarity

• Beta-lactamase CTX-M-14 0.92
• Beta-lactamase CTX-M-25 0.92
• Beta-lactamase CTX-M-8 0.91
• Beta-lactamase OXY-1 0.90
• Beta-lactamase OXY-2 0.90
• Beta-lactamase 0.90
• Beta-lactamase L2 0.90
• Beta-lactamase CTX-M-15 0.89
• Beta-lactamase CTX-M-6 0.88
• Beta-lactamase CTX-M-1 0.88
• Beta-lactamase CTX-M-4 0.88
• Beta-lactamase CTX-M-5 0.88

Co-cited proteins · studied together in the literature

• Beta-lactamase SHV-46 1 shared papers

Literature · 2 cited papers

• Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing beta-lactamase KPC-2. Antimicrob. Agents Chemother. · 2003
• A standard numbering scheme for the class A beta-lactamases. Biochem. J. · 1991