Transient receptor potential cation channel subfamily M member 8

UniProt Q7Z2W7 Organism Homo sapiens Gene LTRPC6, TRPM8, TRPP8

Also known as: LTRPC6, TRPM8, TRPP8

Function

Non-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. Activated by cool temperatures (<23-28 degrees Celsius) and by chemical ligands evoking a sensation of coolness, such as menthol and icilin therefore plays a central role in the detection of environmental cold temperatures. TRPM8 is a voltage-dependent channel; its activation by cold or chemical ligands shifts its voltage thresholds towards physiological membrane potentials, leading to the opening of the channel. In addition to its critical role in temperature sensing, regulates basal tear secretion by sensing evaporation-induced cooling and changes in osmolality (By similarity). May play a role in prostate cancer cell migration.

Classification

Family (Pfam): PF18139 LSDAT_euk, PF25508 TRPM2, PF23317 YVC1_C
InterPro: TRPM, TRPM-like, TRPM_SLOG, YVC1_C
Functional cluster: Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 1

8BDC EM 2.65A

A predicted model is available from AlphaFold.

Gene Ontology · 12

Drugs targeting this protein · 2

MENTHOL opener
ELISMETREP inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

TRPM8 channel-associated factor 1 1 shared papers
TRPM8 channel-associated factor 2 1 shared papers
Transient receptor potential cation channel subfamily V member 6 1 shared papers

Literature · 11 cited papers

Structure of human TRPM8 channel. Commun. Biol. · 2023
TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. J. Cell Biol. · 2015
Regulation of activity of transient receptor potential melastatin 8 (TRPM8) channel by its short isoforms. J. Biol. Chem. · 2012
Trafficking and assembly of the cold-sensitive TRPM8 channel. J. Biol. Chem. · 2006
Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells. J. Biol. Chem. · 2005
PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain. Nat. Neurosci. · 2005
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature · 2004
Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein trp-p8. Prostate · 2003
Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res. · 2001

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