Inactive caspase-12

Function

May function as a negative regulator of inflammatory responses and innate immunity. May reduce cytokine release in response to bacterial lipopolysaccharide during infection. Reduces activation of NF-kappa-B in response to TNF. May lack protease activity (Probable).

Classification

Family (Pfam)

PF00619 CARD, PF00656 Peptidase_C14

InterPro

CARD, Caspase-like_dom_sf, Caspase_cys_AS, DEATH-like_dom_sf, Pept_C14, Pept_C14_caspase, Pept_C14_p10, Pept_C14_p20, Pept_C14A

Functional cluster

Cytochrome P450 & Heme Enzymes

Gene Ontology · 8

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005783 endoplasmic reticulum
• GO:0072558 NLRP1 inflammasome complex
• GO:0008234 cysteine-type peptidase activity
• GO:0050729 positive regulation of inflammatory response
• GO:0043525 positive regulation of neuron apoptotic process
• GO:0006508 proteolysis

Drugs targeting this protein · 1

• EMRICASAN inhibitor

Related proteins · sequence + function similarity

• Caspase-12 0.92
• Caspase-12 0.89
• Caspase-4 0.89
• Caspase-12 0.89
• Caspase-12 0.88
• Caspase-5 0.87
• Caspase-4 0.86
• Caspase-13 0.86
• Caspase-4 0.84
• Caspase-1 0.78
• Caspase-1 0.77
• Caspase-1 0.77

Literature · 6 cited papers

• Population distribution of the functional caspase-12 allele. Hum. Mutat. · 2006
• Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature · 2006
• Spread of an inactive form of caspase-12 in humans is due to recent positive selection. Am. J. Hum. Genet. · 2006
• Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature · 2004
• The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. · 2003
• Human caspase 12 has acquired deleterious mutations. Biochem. Biophys. Res. Commun. · 2002