Substance-P receptor

Function

Receptor for the tachykinin substance P, also able to bind and respond to tachynins neurokinin A/substance K and neurokinin B/neuromedin-K. The rank order of affinity of this receptor to tachykinins is: substance P > neurokinin A/substance K > neurokinin B/neuromedin-K. Substance P binding to its receptor triggers G protein-coupled receptor signaling via activation of phosphatidylinositol hydrolysis by phospholipase C. Substance P binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP).

Classification

Family (Pfam)

PF00001 7tm_1

InterPro

GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Neurokn_rcpt, NK1_rcpt

Functional cluster

Membrane Transporters & GPCRs

Gene Ontology · 10

• GO:0005769 early endosome
• GO:0005886 plasma membrane
• GO:0061827 sperm head
• GO:0097225 sperm midpiece
• GO:0016496 substance P receptor activity
• GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
• GO:0007209 phospholipase C-activating tachykinin receptor signaling pathway
• GO:0007204 positive regulation of cytosolic calcium ion concentration
• GO:1902093 positive regulation of flagellated sperm motility
• GO:0070472 regulation of uterine smooth muscle contraction

Drugs targeting this protein · 2

• MAROPITANT CITRATE antagonist
• MAROPITANT antagonist

Related proteins · sequence + function similarity

• Substance-P receptor 1.00
• Substance-P receptor 1.00
• Substance-P receptor 1.00
• Substance-P receptor 1.00
• Substance-P receptor 1.00
• Substance-P receptor 0.95
• Neuromedin-K receptor 0.93
• Neuromedin-K receptor 0.93
• Neuromedin-K receptor 0.90
• Neuromedin-K receptor 0.89
• Neuromedin-K receptor 0.85
• Substance-K receptor 0.81