lmmol · Proteins

Genome polyprotein

UniProt Q32ZE1 Organism Zika virus EC 3.4.21.91, 3.6.1.15, 3.6.4.13, 2.1.1.56, 2.1.1.57, 2.7.7.48

Function

Capsid protein C self-assembles to form an icosahedral capsid about 30 nm in diameter. The capsid encapsulates the genomic RNA (Probable). Plays a role in virus budding by binding to the host cell membrane and packages the viral RNA into a nucleocapsid that forms the core of the mature virus particle. During virus entry, may induce genome penetration into the host cytoplasm after hemifusion induced by the surface proteins. Can migrate to the cell nucleus where it modulates host functions. Inhibits the integrated stress response (ISR) in the infected cell (By similarity).

Classification

Family (Pfam)
PF20907 Flav_NS3-hel_C, PF01003 Flavi_capsid, PF07652 Flavi_DEAD, PF21659 Flavi_E_stem, PF02832 Flavi_glycop_C, PF00869 Flavi_glycoprot, PF01004 Flavi_M, PF00948 Flavi_NS1, PF01005 Flavi_NS2A, PF01002 Flavi_NS2B, PF01350 Flavi_NS4A, PF01349 Flavi_NS4B, PF00972 Flavi_NS5, PF20483 Flavi_NS5_thumb, PF01570 Flavi_propep, PF01728 FtsJ, PF00949 Peptidase_S7
InterPro
DNA/RNA_pol_sf, Env_glycoprot_M_flavivir, Env_glycoprot_M_sf_flavivir, Flav_gly_cen_dom_subdom1, Flavi_capsidC, Flavi_capsidC_sf, Flavi_DEAD, Flavi_E_Ig-like, Flavi_E_Stem/Anchor_dom, Flavi_E_Stem/Anchor_dom_sf, Flavi_Glycoprot_E_cen/dimer, Flavi_NS1, Flavi_NS2A, Flavi_NS2B, Flavi_NS3_S7, Flavi_NS4A, Flavi_NS4B, Flavi_NS5_thumb, Flavi_propep, Flavi_propep_sf, Flavi_RdRp, Flavi_RdRp_fingers/palm, Flavivir/Alphavir_Ig-like_sf, Gen_Poly_FLV, Glycoprot_cen/dimer_sf, Glycoprot_E_dimer_dom, GlyE_cen_dom_subdom2, Helicase_ATP-bd, Helicase_C-like, Ig_E-set, mRNA_cap_0/1_MeTrfase, NS3-hel_C_flaviviridae, P-loop_NTPase, Peptidase_S1_PA, RNA-dir_pol_PSvirus, RNA_MeTrfase_FtsJ_dom, SAM-dependent_MTases_sf
Functional cluster
DNA-Directed RNA Polymerase Subunits

Experimental structures · PDB · 277

A predicted model is available from AlphaFold.

Gene Ontology · 36

Drugs targeting this protein · 1

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 37 cited papers

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