Large ribosomal subunit protein uL5

Function

This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

Classification

Family (Pfam)

PF00281 Ribosomal_L5, PF00673 Ribosomal_L5_C

InterPro

Ribosomal_uL5, Ribosomal_uL5_bact, Ribosomal_uL5_C, Ribosomal_uL5_CS, Ribosomal_uL5_dom_sf, Ribosomal_uL5_N

Functional cluster

Large Ribosomal Subunit Proteins

Experimental structures · PDB · 21

• 4WCE X-ray 3.53A
• 4WF9 X-ray 3.43A
• 4WFA X-ray 3.39A
• 4WFB X-ray 3.43A
• 5HKV X-ray 3.66A
• 5HL7 X-ray 3.55A
• 5LI0 EM 3.80A
• 5ND8 EM 3.70A
• 5ND9 EM 3.70A
• 5NRG X-ray 3.44A
• 5TCU EM 3.90A
• 6HMA EM 2.65A
• … and 9 more

A predicted model is available from AlphaFold.

Gene Ontology · 6

• GO:0022625 cytosolic large ribosomal subunit
• GO:0003723 RNA binding
• GO:0019843 rRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0000049 tRNA binding
• GO:0006412 translation

Drugs targeting this protein · 1

• RETAPAMULIN inhibitor

Related proteins · sequence + function similarity

• Large ribosomal subunit protein uL5 1.00
• Large ribosomal subunit protein uL5 1.00
• Large ribosomal subunit protein uL5 1.00
• Large ribosomal subunit protein uL5 1.00
• Large ribosomal subunit protein uL5 1.00
• Large ribosomal subunit protein uL5 1.00
• Large ribosomal subunit protein uL5 1.00
• Large ribosomal subunit protein uL5 1.00
• Large ribosomal subunit protein uL5 1.00
• Large ribosomal subunit protein uL5 1.00
• Large ribosomal subunit protein uL5 1.00
• Large ribosomal subunit protein uL5 1.00