Large ribosomal subunit protein uL22
Also known as: SAOUHSC_02507, rplV
Function
This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).
Classification
- Family (Pfam)
- PF00237 Ribosomal_L22
- InterPro
- Ribosomal_uL22, Ribosomal_uL22_bac/chlpt-type, Ribosomal_uL22_bact_org, Ribosomal_uL22_CS, Ribosomal_uL22_sf
- Functional cluster
- Ribosomal Proteins (S5/S18, L17/L22)
Experimental structures · PDB · 31
- 4WCE X-ray 3.53A
- 4WF9 X-ray 3.43A
- 4WFA X-ray 3.39A
- 4WFB X-ray 3.43A
- 5HKV X-ray 3.66A
- 5HL7 X-ray 3.55A
- 5LI0 EM 3.80A
- 5ND8 EM 3.70A
- 5ND9 EM 3.70A
- 5NRG X-ray 3.44A
- 5TCU EM 3.90A
- 6DDD EM 3.10A
- … and 19 more
A predicted model is available from AlphaFold.
Gene Ontology · 4
Drugs targeting this protein · 1
- RETAPAMULIN inhibitor
Related proteins · sequence + function similarity
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
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