Large ribosomal subunit protein uL4
Also known as: SAOUHSC_02511, rplD
Function
One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
Classification
- Family (Pfam)
- PF00573 Ribosomal_L4
- InterPro
- Ribosomal_uL4, Ribosomal_uL4-like, Ribosomal_uL4_dom_sf
- Functional cluster
- Large-Subunit Ribosomal Proteins (L4/L20/L35)
Experimental structures · PDB · 31
- 4WCE X-ray 3.53A
- 4WF9 X-ray 3.43A
- 4WFA X-ray 3.39A
- 4WFB X-ray 3.43A
- 5HKV X-ray 3.66A
- 5HL7 X-ray 3.55A
- 5LI0 EM 3.80A
- 5ND8 EM 3.70A
- 5ND9 EM 3.70A
- 5NRG X-ray 3.44A
- 5TCU EM 3.90A
- 6DDD EM 3.10A
- … and 19 more
A predicted model is available from AlphaFold.
Gene Ontology · 5
Drugs targeting this protein · 1
- RETAPAMULIN inhibitor
Related proteins · sequence + function similarity
- Large ribosomal subunit protein uL4 1.00
- Large ribosomal subunit protein uL4 1.00
- Large ribosomal subunit protein uL4 1.00
- Large ribosomal subunit protein uL4 1.00
- Large ribosomal subunit protein uL4 1.00
- Large ribosomal subunit protein uL4 1.00
- Large ribosomal subunit protein uL4 1.00
- Large ribosomal subunit protein uL4 1.00
- Large ribosomal subunit protein uL4 1.00
- Large ribosomal subunit protein uL4 1.00
- Large ribosomal subunit protein uL4 1.00
- Large ribosomal subunit protein uL4 0.99
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