Potassium voltage-gated channel subfamily A member 10
Also known as: KCNA10
Function
Voltage-gated potassium ion channel that mediates K(+) permeability of excitable membranes. When opened in response to the voltage difference across the membrane, KCNA10 channel selectively allows the flow of potassium ions across the membrane down their electrochemical gradient.
Classification
- Family (Pfam)
- PF02214 BTB_2, PF00520 Ion_trans
- InterPro
- BTB/POZ_dom, Ion_trans_dom, K_chnl_volt-dep_Kv, K_chnl_volt-dep_Kv1, SKP1/BTB/POZ_sf, T1-type_BTB, VG_K_chnl, Volt_channel_dom_sf
- Functional cluster
- Ribosome-Recycling & Clp Protease Factors
Gene Ontology · 10
- GO:0016020 membrane
- GO:0005886 plasma membrane
- GO:0008076 voltage-gated potassium channel complex
- GO:0005251 delayed rectifier potassium channel activity
- GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity
- GO:0005249 voltage-gated potassium channel activity
- GO:0001508 action potential
- GO:0071805 potassium ion transmembrane transport
- GO:0006813 potassium ion transport
- GO:0051260 protein homooligomerization
Drugs targeting this protein · 6
- TEDISAMIL blocker
- GUANIDINE HYDROCHLORIDE blocker
- NERISPIRDINE blocker
- DALFAMPRIDINE blocker
- AMIFAMPRIDINE PHOSPHATE blocker
- AMIFAMPRIDINE blocker
Related proteins · sequence + function similarity
- Potassium voltage-gated channel subfamily A member 10 1.00
- Potassium voltage-gated channel subfamily A member 2 0.97
- Potassium voltage-gated channel subfamily A member 10 0.97
- Potassium voltage-gated channel subfamily A member 1 0.96
- Potassium voltage-gated channel subfamily A member 1 0.96
- Potassium voltage-gated channel subfamily A member 2 0.96
- Potassium voltage-gated channel subfamily A member 2 0.96
- Potassium voltage-gated channel subfamily A member 1 0.96
- Potassium voltage-gated channel subfamily A member 2 0.96
- Potassium voltage-gated channel subfamily A member 2 0.96
- Potassium voltage-gated channel subfamily A member 2 0.95
- Potassium voltage-gated channel subfamily A member 2 0.95
Literature · 7 cited papers
- The consensus coding sequences of human breast and colorectal cancers. Science · 2006
- The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule. J. Am. Soc. Nephrol. · 2002
- Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit. Am. J. Physiol. · 2002
- KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels. Am. J. Physiol. · 2000
- Genomic localization of the human gene for KCNA10, a cGMP-activated K channel. Genomics · 1997
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