Neuropeptide Y receptor type 5
Also known as: NPY5R, NPYR5
Function
Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, NPY5_rcpt, NPY_rcpt
- Functional cluster
- G Protein-Coupled Receptors
Gene Ontology · 24
- GO:0097731 9+0 non-motile cilium
- GO:0098982 GABA-ergic synapse
- GO:0043005 neuron projection
- GO:0005886 plasma membrane
- GO:0098793 presynapse
- GO:0004983 neuropeptide Y receptor activity
- GO:0001602 pancreatic polypeptide receptor activity
- GO:0001601 peptide YY receptor activity
- GO:0003214 cardiac left ventricle morphogenesis
- GO:0007268 chemical synaptic transmission
- GO:0042755 eating behavior
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0060112 generation of ovulation cycle rhythm
- GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus
- GO:0043066 negative regulation of apoptotic process
- GO:0014050 negative regulation of glutamate secretion
- GO:0032229 negative regulation of synaptic transmission, GABAergic
- GO:0007218 neuropeptide signaling pathway
- GO:0003151 outflow tract morphogenesis
- GO:0002675 positive regulation of acute inflammatory response
- GO:0070374 positive regulation of ERK1 and ERK2 cascade
- GO:0048661 positive regulation of smooth muscle cell proliferation
- GO:0045471 response to ethanol
- GO:0099538 synaptic signaling via neuropeptide
Drugs targeting this protein · 2
- VELNEPERIT antagonist
- MK-0557 antagonist
Related proteins · sequence + function similarity
- Neuropeptide Y receptor type 5 0.99
- Neuropeptide Y receptor type 5 0.98
- Neuropeptide Y receptor type 5 0.96
- Neuropeptide Y receptor type 5 0.95
- Neuropeptide receptor npr-1 0.85
- Putative neuropeptide Y receptor 11 0.84
- Neuropeptide receptor 3 0.84
- D(1B) dopamine receptor 0.82
- D(1A) dopamine receptor 0.82
- D(1A) dopamine receptor 0.81
- D(1A) dopamine receptor 0.81
- D(1A) dopamine receptor 0.81
Co-cited proteins · studied together in the literature
- Neuropeptide Y receptor type 5 2 shared papers
Literature · 5 cited papers
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation. Genomics · 1997
- Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. J. Biol. Chem. · 1996
- A receptor subtype involved in neuropeptide-Y-induced food intake. Nature · 1996
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