ELAV-like protein 1

UniProt Q15717 Organism Homo sapiens Gene ELAVL1, HUR

Also known as: ELAVL1, HUR

Function

RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR.

Classification

Family (Pfam): PF00076 RRM_1
InterPro: ELAD_HU_SF, Hud_Sxl_RNA, HuR_RRM2, Nucleotide-bd_a/b_plait_sf, RBD_domain_sf, RRM_dom
Functional cluster: Protein Serine/Threonine Kinases

Experimental structures · PDB · 10

3HI9 X-ray 2.00A
4ED5 X-ray 2.00A
4EGL X-ray 2.90A
4FXV X-ray 1.90A
5SZW NMR
6G2K X-ray 2.01A
6GC5 X-ray 1.90A
6GD1 X-ray 2.01A
6GD2 X-ray 1.90A
6GD3 X-ray 1.35A

A predicted model is available from AlphaFold.

Gene Ontology · 37

Neighborhood · nearest proteins

Nearest neighbours of ELAV-like protein 1: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Pleckstrin homology domain-containing family N member 1 3 shared papers
ELAV-like protein 1 1 shared papers
Probable pleckstrin homology domain-containing family N member 1 1 shared papers
ELAV-like protein 1 2 shared papers
Protein kinase C delta type 1 shared papers
Putative RNA-binding regulatory peptide 1 shared papers
Acidic leucine-rich nuclear phosphoprotein 32 family member A 1 shared papers
Heterogeneous nuclear ribonucleoprotein L 1 shared papers
RNA-binding protein FXR1 1 shared papers
MAP kinase-activated protein kinase 2 1 shared papers
Y-box-binding protein 1 4 shared papers
Insulin-like growth factor 2 mRNA-binding protein 1 5 shared papers

Literature · 38 cited papers

An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis. Nat. Commun. · 2020
5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs. Nat. Cell Biol. · 2019
FXR1 is an IL-19-responsive RNA-binding protein that destabilizes pro-inflammatory transcripts in vascular smooth muscle cells. Cell Rep. · 2018
Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat. Cell Biol. · 2018
Role of N-myristoylation in stability and subcellular localization of the CLPABP protein. Biochem. Biophys. Res. Commun. · 2018
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
IRAV (FLJ11286), an Interferon-Stimulated Gene with Antiviral Activity against Dengue Virus, Interacts with MOV10. J. Virol. · 2017
Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse. Biochim. Biophys. Acta · 2016
N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol. Cell. Proteomics · 2014
Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains. Biol. Chem. · 2013
The structure of the ARE-binding domains of Hu antigen R (HuR) undergoes conformational changes during RNA binding. Acta Crystallogr. D · 2013
… and 26 more in the literature graph

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