Delta(24)-sterol reductase

Function

Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.

Classification

Family (Pfam)

PF01565 FAD_binding_4

InterPro

Diminuto-like, FAD-bd_PCMH, FAD-bd_PCMH-like_sf, FAD-bd_PCMH_sub2, Oxid_FAD_bind_N

Functional cluster

Zinc-Finger & Ubiquitination Proteins

Gene Ontology · 21

• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005789 endoplasmic reticulum membrane
• GO:0000139 Golgi membrane
• GO:0016020 membrane
• GO:0005634 nucleus
• GO:0000246 Delta24(24-1) sterol reductase activity
• GO:0050614 Delta24-sterol reductase activity
• GO:0019899 enzyme binding
• GO:0071949 FAD binding
• GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
• GO:0042605 peptide antigen binding
• GO:0006695 cholesterol biosynthetic process
• GO:0033489 cholesterol biosynthetic process via desmosterol
• GO:0033490 cholesterol biosynthetic process via lathosterol
• GO:0008285 negative regulation of cell population proliferation
• GO:0007265 Ras protein signal transduction
• GO:0009725 response to hormone
• GO:0043588 skin development
• GO:0008202 steroid metabolic process
• GO:0009888 tissue development

Disease associations

• desmosterolosis MONDO:0011217

Drugs targeting this protein · 1

• TRIPARANOL inhibitor

Related proteins · sequence + function similarity

• Delta(24)-sterol reductase 1.00
• Delta(24)-sterol reductase 1.00
• Delta(24)-sterol reductase 1.00
• Delta(24)-sterol reductase homolog dhcr-24 0.84
• L-gulonolactone oxidase 0.73
• Delta(24)-sterol reductase 0.71
• L-gulonolactone oxidase 0.69
• L-gulonolactone oxidase 0.67
• L-gulonolactone oxidase 0.67
• Delta(24)-sterol reductase 0.66
• L-gulonolactone oxidase 0.65
• D-arabinono-1,4-lactone oxidase 0.63

Co-cited proteins · studied together in the literature

• Delta(24)-sterol reductase 1 shared papers
• 7-dehydrocholesterol reductase 1 shared papers

Literature · 13 cited papers

• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally. J. Lipid Res. · 2015
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1). Biochim. Biophys. Acta · 2012
• The membrane topological analysis of 3 {beta}-hydroxysteroid-delta24 reductase (DHCR24) on endoplasmic reticulum. J. Mol. Endocrinol. · 2012
• Desmosterolosis-phenotypic and molecular characterization of a third case and review of the literature. Am. J. Med. Genet. A · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Mutations in the 3beta-hydroxysterol delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis. Am. J. Hum. Genet. · 2001
• The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress. J. Neurosci. · 2000
• … and 1 more in the literature graph