Metabotropic glutamate receptor 4

Function

G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Classification

Family (Pfam)

PF00003 7tm_3, PF01094 ANF_receptor, PF07562 NCD3G

InterPro

ANF_lig-bd_rcpt, GPCR_3, GPCR_3_9-Cys_dom, GPCR_3_9-Cys_sf, GPCR_3_C, GPCR_3_CS, GPCR_3_mGluR4, GPCR_3_mtglu_rcpt, mGluR, Peripla_BP_I

Functional cluster

Secreted Growth Factors & Cytokines

Experimental structures · PDB · 8

• 7E9H EM 4.00A
• 8JD4 EM 2.90A
• 8JD5 EM 3.60A
• 8JD6 EM 3.40A
• 8WG9 EM 4.46A
• 8WGB EM 3.70A
• 8WGC EM 5.95A
• 8WGD EM 4.45A

A predicted model is available from AlphaFold.

Gene Ontology · 13

• GO:0031410 cytoplasmic vesicle
• GO:0005886 plasma membrane
• GO:0098793 presynapse
• GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
• GO:0004930 G protein-coupled receptor activity
• GO:0008066 glutamate receptor activity
• GO:0007196 adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
• GO:0007268 chemical synaptic transmission
• GO:0007216 G protein-coupled glutamate receptor signaling pathway
• GO:0007269 neurotransmitter secretion
• GO:0043410 positive regulation of MAPK cascade
• GO:0043523 regulation of neuron apoptotic process
• GO:0051966 regulation of synaptic transmission, glutamatergic

Drugs targeting this protein · 1

• FOLIGLURAX positive allosteric modulator

Related proteins · sequence + function similarity

• Metabotropic glutamate receptor 4 1.00
• Metabotropic glutamate receptor 4 1.00
• Metabotropic glutamate receptor 4 1.00
• Metabotropic glutamate receptor 6 0.89
• Metabotropic glutamate receptor 6 0.89
• Metabotropic glutamate receptor 6 0.87
• Metabotropic glutamate receptor 6 0.86
• Metabotropic glutamate receptor 8 0.85
• Metabotropic glutamate receptor 7 0.83
• Metabotropic glutamate receptor 8 0.83
• Metabotropic glutamate receptor 8 0.83
• Metabotropic glutamate receptor 7 0.83

Co-cited proteins · studied together in the literature

• Metabotropic glutamate receptor 8 1 shared papers
• Metabotropic glutamate receptor 7 1 shared papers

Literature · 6 cited papers

• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• The DNA sequence and analysis of human chromosome 6. Nature · 2003
• Mutation screening of the metabotropic glutamate receptor mGluR4 (GRM4) gene in patients with schizophrenia. Psychiatr. Genet. · 2001
• Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. Brain Res. Mol. Brain Res. · 1998
• Molecular characterization and localization of human metabotropic glutamate receptor type 4. Brain Res. Mol. Brain Res. · 1996
• Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 4. Neuropharmacology · 1995