Metabotropic glutamate receptor 3
Also known as: GPRC1C, GRM3, MGLUR3
Function
G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Classification
- Family (Pfam)
- PF00003 7tm_3, PF01094 ANF_receptor, PF07562 NCD3G
- InterPro
- ANF_lig-bd_rcpt, GPCR_3, GPCR_3_9-Cys_dom, GPCR_3_9-Cys_sf, GPCR_3_C, GPCR_3_CS, GPCR_3_mGluR3, GPCR_3_mtglu_rcpt, mGluR, Peripla_BP_I
- Functional cluster
- Immunoglobulin-Domain Cell Adhesion Proteins
Experimental structures · PDB · 20
- 3SM9 X-ray 2.26A
- 4XAR X-ray 2.26A
- 5CNK X-ray 3.15A
- 5CNM X-ray 2.84A
- 6B7H X-ray 2.82A
- 7WI6 EM 3.71A
- 7WI8 EM 4.17A
- 7WIH EM 3.68A
- 8JCU EM 2.80A
- 8JCV EM 3.40A
- 8JCW EM 3.00A
- 8JCX EM 3.00A
- … and 8 more
A predicted model is available from AlphaFold.
Gene Ontology · 18
- GO:0097449 astrocyte projection
- GO:0030424 axon
- GO:0043197 dendritic spine
- GO:0098978 glutamatergic synapse
- GO:0005886 plasma membrane
- GO:0014069 postsynaptic density
- GO:0045211 postsynaptic membrane
- GO:0042734 presynaptic membrane
- GO:0005246 calcium channel regulator activity
- GO:0004930 G protein-coupled receptor activity
- GO:0008066 glutamate receptor activity
- GO:0001641 group II metabotropic glutamate receptor activity
- GO:0097110 scaffold protein binding
- GO:0007268 chemical synaptic transmission
- GO:0007216 G protein-coupled glutamate receptor signaling pathway
- GO:0007194 negative regulation of adenylate cyclase activity
- GO:0099170 postsynaptic modulation of chemical synaptic transmission
- GO:0051966 regulation of synaptic transmission, glutamatergic
Drugs targeting this protein · 3
- POMAGLUMETAD METHIONIL ANHYDROUS agonist
- DECOGLURANT modulator
- LY404039 agonist
Related proteins · sequence + function similarity
- Metabotropic glutamate receptor 3 1.00
- Metabotropic glutamate receptor 3 1.00
- Metabotropic glutamate receptor 3 1.00
- Metabotropic glutamate receptor 3 1.00
- Metabotropic glutamate receptor 0.92
- Metabotropic glutamate receptor 1 0.92
- Metabotropic glutamate receptor 1 0.92
- Metabotropic glutamate receptor 1 0.91
- Metabotropic glutamate receptor 5 0.90
- Metabotropic glutamate receptor 5 0.90
- Metabotropic glutamate receptor 5 0.90
- Probable metabotropic glutamate receptor mgl-1 0.89
Literature · 4 cited papers
- Alternative splicing of human metabotropic glutamate receptor 3. J. Neurochem. · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- The DNA sequence of human chromosome 7. Nature · 2003
- Molecular characterization and localization of human metabotropic glutamate receptor type 3. Brain Res. Mol. Brain Res. · 1996
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