lmmol · Proteins

Spliceosome RNA helicase DDX39B

UniProt Q13838 Organism Homo sapiens Gene BAT1, DDX39B, UAP56 EC 3.6.4.13

Also known as: BAT1, DDX39B, UAP56

Function

Involved in nuclear export of spliced and unspliced mRNA. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. The THOC1-THOC2-THOC3 core complex alone is sufficient to promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B. Associates with SARNP/CIP29, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC4 and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability.

Classification

Family (Pfam)
PF00270 DEAD, PF00271 Helicase_C
InterPro
DEAD/DEAH_box_helicase_dom, Helicase_ATP-bd, Helicase_C-like, P-loop_NTPase, RNA_helicase_DEAD_Q_motif
Functional cluster
Serine/Threonine Protein Kinases

Experimental structures · PDB · 12

A predicted model is available from AlphaFold.

Gene Ontology · 23

Neighborhood · nearest proteins

BAT1BAT1BAT1BAT1ALYHPR1CXorf3
Nearest neighbours of Spliceosome RNA helicase DDX39B: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 39 cited papers

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