Apoptosis-stimulating of p53 protein 2

Function

Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.

Classification

Family (Pfam)

PF12796 Ank_2, PF21801 ASPP2-like_RA, PF00018 SH3_1

InterPro

Ankyrin_rpt, Ankyrin_rpt-contain_sf, ASPP1/2, ASPP2-like_RA, ASPP2_RA, SH3-like_dom_sf, SH3_domain, Ubiquitin-like_domsf

Functional cluster

RNA Polymerase II Transcription Factors

Experimental structures · PDB · 6

• 1YCS X-ray 2.20A
• 2UWQ NMR
• 4A63 X-ray 2.27A
• 4IRV X-ray 2.04A
• 6GHM X-ray 2.15A
• 6HKP X-ray 1.90A

A predicted model is available from AlphaFold.

Gene Ontology · 15

• GO:0030054 cell junction
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0048471 perinuclear region of cytoplasm
• GO:0042802 identical protein binding
• GO:0051059 NF-kappaB binding
• GO:0002039 p53 binding
• GO:0042803 protein homodimerization activity
• GO:0017124 SH3 domain binding
• GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
• GO:0045786 negative regulation of cell cycle
• GO:1900119 positive regulation of execution phase of apoptosis
• GO:0007165 signal transduction

Neighborhood · nearest proteins

Related proteins · sequence + function similarity

• Apoptosis-stimulating of p53 protein 2 0.99
• Apoptosis-stimulating of p53 protein 1 0.91
• Apoptosis-stimulating of p53 protein 1 0.90
• Cortactin-binding protein 2 0.77
• Cortactin-binding protein 2 0.77
• Cortactin-binding protein 2 0.76
• Cortactin-binding protein 2 0.75
• Cortactin-binding protein 2 0.75
• Cortactin-binding protein 2 0.75
• Cortactin-binding protein 2 0.75
• LIM and calponin homology domains-containing protein 1 0.75
• LIM and calponin homology domains-containing protein 1 0.75

Co-cited proteins · studied together in the literature

• Apoptosis-stimulating of p53 protein 1 2 shared papers
• ATP-dependent RNA helicase DDX42 1 shared papers
• Adenomatous polyposis coli protein 2 1 shared papers
• NEDD8-activating enzyme E1 regulatory subunit 1 shared papers
• Apoptotic enhancer 1 protein 1 shared papers
• Apoptosis regulator Bcl-2 1 shared papers
• TP53-binding protein 1 1 shared papers
• RelA-associated inhibitor 1 shared papers
• Transcription factor p65 1 shared papers
• Palmitoyltransferase ZDHHC17 1 shared papers
• Neurogenic locus notch homolog protein 1 1 shared papers
• Cellular tumor antigen p53 2 shared papers

Literature · 25 cited papers

• Identifying tandem Ankyrin repeats in protein structures. BMC Bioinformatics · 2014
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
• Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
• The DEAD box protein Ddx42p modulates the function of ASPP2, a stimulator of apoptosis. Oncogene · 2009
• A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
• Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like fold. J. Mol. Biol. · 2007
• The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• … and 13 more in the literature graph