Ileal sodium/bile acid cotransporter

UniProt Q12908 Organism Homo sapiens Gene ASBT, ISBT, NTCP2, SLC10A2

Also known as: ASBT, ISBT, NTCP2, SLC10A2

Function

Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate. Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids (Probable). Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation.

Classification

Family (Pfam): PF01758 SBF
InterPro: BilAc:Na_symport/Acr3, Bilac:Na_transpt, Na+/solute_symporter_sf
Functional cluster: Membrane Transporters & GPCRs

Gene Ontology · 5

Disease associations

bile acid malabsorption, primary, 1 MONDO:0013214

Drugs targeting this protein · 7

MARALIXIBAT CHLORIDE inhibitor
LINERIXIBAT inhibitor
ELOBIXIBAT inhibitor
MARALIXIBAT inhibitor
VOLIXIBAT inhibitor
ODEVIXIBAT inhibitor
ODEVIXIBAT SESQUIHYDRATE inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Hepatic sodium/bile acid cotransporter 2 shared papers
Ileal sodium/bile acid cotransporter 1 shared papers
Integrin beta-like protein 1 1 shared papers
Fibroblast growth factor 14 1 shared papers
Sodium leak channel NALCN 1 shared papers
D-amino acid oxidase regulator 1 shared papers
D-amino-acid oxidase 1 shared papers

Literature · 11 cited papers

Targeting the Four Pillars of Enterohepatic Bile Salt Cycling; Lessons From Genetics and Pharmacology. Hepatology · 2021
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Topology scanning and putative three-dimensional structure of the extracellular binding domains of the apical sodium-dependent bile acid transporter (SLC10A2). Biochemistry · 2004
The DNA sequence and analysis of human chromosome 13. Nature · 2004
Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc. Natl. Acad. Sci. U.S.A. · 2002
Analysis of the ileal bile acid transporter gene, SLC10A2, in subjects with familial hypertriglyceridemia. Arterioscler. Thromb. Vasc. Biol. · 2001
Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption. Scand. J. Gastroenterol. · 2001
Bile acid uptake via the human apical sodium-bile acid cotransporter is electrogenic. J. Biol. Chem. · 1998
Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am. J. Physiol. · 1998
Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2). J. Clin. Invest. · 1997
Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity. J. Biol. Chem. · 1995

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