Dihydropyrimidine dehydrogenase [NADP(+)]

Function

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.

Classification

Family (Pfam)

PF01180 DHO_dh, PF14691 Fer4_20, PF14697 Fer4_21, PF07992 Pyr_redox_2

InterPro

4Fe4S_Fe-S-bd, 4Fe4S_Fe_S_CS, Aldolase_TIM, Dihydroorotate_DH_cat, DPD_II, FAD/NAD-bd_sf, FAD/NAD-binding_dom, Helical_ferredxn

Functional cluster

S-Adenosylmethionine Synthases & related

Gene Ontology · 21

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0051539 4 iron, 4 sulfur cluster binding
• GO:0017113 dihydropyrimidine dehydrogenase (NADP+) activity
• GO:0050660 flavin adenine dinucleotide binding
• GO:0046872 metal ion binding
• GO:0050661 NADP binding
• GO:0042803 protein homodimerization activity
• GO:0002058 uracil binding
• GO:0019483 beta-alanine biosynthetic process
• GO:0006248 CMP catabolic process
• GO:0006249 dCMP catabolic process
• GO:0046079 dUMP catabolic process
• GO:0006145 purine nucleobase catabolic process
• GO:0006208 pyrimidine nucleobase catabolic process
• GO:0006214 thymidine catabolic process
• GO:0006210 thymine catabolic process
• GO:0046045 TMP catabolic process
• GO:0046050 UMP catabolic process
• GO:0006212 uracil catabolic process
• GO:0042178 xenobiotic catabolic process

Disease associations

• dihydropyrimidine dehydrogenase deficiency MONDO:0010130

Drugs targeting this protein · 2

• GIMERACIL inhibitor
• ENILURACIL inhibitor

Related proteins · sequence + function similarity

• Dihydropyrimidine dehydrogenase [NADP(+)] 1.00
• Dihydropyrimidine dehydrogenase [NADP(+)] 0.99
• Dihydropyrimidine dehydrogenase [NADP(+)] 0.99
• Dihydropyrimidine dehydrogenase [NADP(+)] 0.98
• Dihydropyrimidine dehydrogenase [NADP(+)] 0.98
• Dihydropyrimidine dehydrogenase [NADP(+)] 0.97
• Dihydropyrimidine dehydrogenase [NADP(+)] 0.83
• Probable dihydropyrimidine dehydrogenase [NADP(+)] 0.80
• Dihydropyrimidine dehydrogenase [NADP(+)] 0.78
• Betaine--homocysteine S-methyltransferase 1 0.67
• Betaine--homocysteine S-methyltransferase 1 0.67
• Glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1, cytosolic 0.66

Co-cited proteins · studied together in the literature

• Dihydropyrimidine dehydrogenase [NADP(+)] 1 shared papers
• Histone-lysine N-methyltransferase, H3 lysine-36 specific 1 shared papers
• Aromatase 1 shared papers
• Adhesion G protein-coupled receptor A1 1 shared papers
• Myosin-1 1 shared papers
• Disks large homolog 5 1 shared papers
• Collagen alpha-1(XVIII) chain 1 shared papers
• Receptor-type tyrosine-protein phosphatase T 1 shared papers
• Cadherin-related family member 2 1 shared papers
• Thyroid receptor-interacting protein 11 1 shared papers
• Methylenetetrahydrofolate reductase (NADPH) 1 shared papers
• Interleukin-1 receptor antagonist protein 1 shared papers

Literature · 18 cited papers

• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature · 2008
• The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects. Br. J. Clin. Pharmacol. · 1998
• Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer. Br. J. Cancer · 1998
• Suicidal inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil derived from the antiviral, sorivudine. Cancer Lett. · 1998
• Dihydropyrimidine dehydrogenase (DPD) deficiency: identification and expression of missense mutations C29R, R886H and R235W. Hum. Genet. · 1997
• … and 6 more in the literature graph