3-hydroxy-3-methylglutaryl-coenzyme A reductase

Function

Part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA). Hmg1 catalyzes the reduction of hydroxymethylglutaryl-CoA (HMG-CoA) to mevalonate. The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase eg10 that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthases erg13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases hcs1 (Probable).

Classification

Family (Pfam)

PF00368 HMG-CoA_red, PF12349 Sterol-sensing

InterPro

HMG_CoA_Rdtase, HMG_CoA_Rdtase_cat_sf, HMG_CoA_Rdtase_CS, HMG_CoA_Rdtase_eu_arc, HMG_CoA_Rdtase_N, HMG_CoA_Rdtase_NAD(P)-bd_sf, HMG_CoA_Rdtase_sub-bd_dom_sf, HMGCR/SNAP/NPC1-like_SSD, SSD

Functional cluster

Purine Biosynthesis Enzymes & related

Gene Ontology · 13

• GO:0005783 endoplasmic reticulum
• GO:0005789 endoplasmic reticulum membrane
• GO:0005635 nuclear envelope
• GO:0031965 nuclear membrane
• GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network
• GO:0005778 peroxisomal membrane
• GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity
• GO:0032935 sterol sensor activity
• GO:0015936 coenzyme A metabolic process
• GO:0006696 ergosterol biosynthetic process
• GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway
• GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
• GO:0008299 isoprenoid biosynthetic process

Drugs targeting this protein · 1

• BIFONAZOLE inhibitor

Related proteins · sequence + function similarity

• 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 0.89
• 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 0.86
• 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 0.85
• 3-hydroxy-3-methylglutaryl coenzyme A reductase mokG 0.85
• 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.84
• 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 0.82
• 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 0.79
• 3-hydroxy-3-methylglutaryl coenzyme A reductase mlcD 0.77
• 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.76
• 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.76
• 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.76
• 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.72

Co-cited proteins · studied together in the literature

• Hydroxymethylglutaryl-CoA synthase 2 shared papers
• Acetyl-CoA acetyltransferase 1 shared papers

Literature · 4 cited papers

• Pleiotropic phenotypes caused by an opal nonsense mutation in an essential gene encoding HMG-CoA reductase in fission yeast. Genes Cells · 2009
• Phosphoproteome analysis of fission yeast. J. Proteome Res. · 2008
• The genome sequence of Schizosaccharomyces pombe. Nature · 2002
• Molecular, functional and evolutionary characterization of the gene encoding HMG-CoA reductase in the fission yeast, Schizosaccharomyces pombe. Yeast · 1996