Voltage-dependent calcium channel gamma-1 subunit

Function

Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.

Classification

Family (Pfam)

PF13903 Claudin_2

InterPro

PMP22/EMP/MP20/Claudin, VDCC_g1su, VDCC_gsu

Functional cluster

Respiratory Chain & ATP Synthase Subunits

Gene Ontology · 9

• GO:1990454 L-type voltage-gated calcium channel complex
• GO:0005886 plasma membrane
• GO:0042383 sarcolemma
• GO:0030315 T-tubule
• GO:0005246 calcium channel regulator activity
• GO:0005245 voltage-gated calcium channel activity
• GO:0070588 calcium ion transmembrane transport
• GO:0045933 positive regulation of muscle contraction
• GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

Drugs targeting this protein · 9

• PREGABALIN modulator
• BEPRIDIL HYDROCHLORIDE blocker
• GABAPENTIN ENACARBIL modulator
• IMAGABALIN modulator
• SULOCTIDIL blocker
• PHLOROGLUCINOL blocker
• TERODILINE HYDROCHLORIDE blocker
• ATAGABALIN modulator
• GABAPENTIN modulator

Related proteins · sequence + function similarity

• Voltage-dependent calcium channel gamma-1 subunit 0.99
• Voltage-dependent calcium channel gamma-1 subunit 0.98
• Voltage-dependent calcium channel gamma-1 subunit 0.97
• Voltage-dependent calcium channel gamma-1 subunit 0.97
• Voltage-dependent calcium channel gamma-1 subunit 0.95
• Claudin domain-containing protein 1 0.83
• Voltage-dependent calcium channel gamma-6 subunit 0.83
• Claudin domain-containing protein 1 0.83
• Claudin domain-containing protein 1 0.82
• Claudin domain-containing protein 1 0.82
• Voltage-dependent calcium channel gamma-6 subunit 0.82
• Transmembrane protein 114 0.82

Literature · 4 cited papers

• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Localization of the gamma-subunit of the skeletal muscle L-type voltage-dependent calcium channel gene (CACNLG) to human chromosome band 17q24 by in situ hybridization and identification of a polymorphic repetitive DNA sequence at the gene locus. Cytogenet. Cell Genet. · 1993
• Molecular characterization of the gene encoding the gamma subunit of the human skeletal muscle 1,4-dihydropyridine-sensitive Ca2+ channel (CACNLG), cDNA sequence, gene structure, and chromosomal location. J. Biol. Chem. · 1993