Amidophosphoribosyltransferase
Also known as: GPAT, PPAT
Function
Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
Classification
- Family (Pfam)
- PF13522 GATase_6, PF00156 Pribosyltran
- InterPro
- GATase_2_dom, Ntn_hydrolases_N, PRTase-like, PRTase_dom, PurF, PurF_N
- Functional cluster
- S-Adenosylmethionine Synthases & related
Gene Ontology · 10
- GO:0005829 cytosol
- GO:0051539 4 iron, 4 sulfur cluster binding
- GO:0004044 amidophosphoribosyltransferase activity
- GO:0046872 metal ion binding
- GO:0044208 'de novo' AMP biosynthetic process
- GO:0006189 'de novo' IMP biosynthetic process
- GO:0097294 'de novo' XMP biosynthetic process
- GO:0006177 GMP biosynthetic process
- GO:0009113 purine nucleobase biosynthetic process
- GO:0006164 purine nucleotide biosynthetic process
Drugs targeting this protein · 3
- AZATHIOPRINE SODIUM inhibitor
- MERCAPTOPURINE inhibitor
- AZATHIOPRINE inhibitor
Related proteins · sequence + function similarity
- Amidophosphoribosyltransferase 0.99
- Amidophosphoribosyltransferase 0.99
- Amidophosphoribosyltransferase 0.98
- Amidophosphoribosyltransferase 0.90
- Amidophosphoribosyltransferase 0.66
- Asparagine synthetase [glutamine-hydrolyzing] 0.61
- Amidophosphoribosyltransferase 0.61
- Asparagine synthetase [glutamine-hydrolyzing] 0.60
- Asparagine synthetase [glutamine-hydrolyzing] 0.60
- Amidophosphoribosyltransferase 0.60
- Asparagine synthetase [glutamine-hydrolyzing] 0.60
- Asparagine synthetase [glutamine-hydrolyzing] 0.59
Literature · 5 cited papers
- N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
- Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Molecular cloning of human amidophosphoribosyltransferase. Biochem. Biophys. Res. Commun. · 1993
- Two genes for de novo purine nucleotide synthesis on human chromosome 4 are closely linked and divergently transcribed. J. Biol. Chem. · 1994
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