DNA topoisomerase 2-beta

UniProt Q02880 Organism Homo sapiens Gene TOP2B EC 5.6.2.2

Also known as: TOP2B

Function

Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation.

Classification

Family (Pfam): PF00204 DNA_gyraseB, PF00521 DNA_topoisoIV, PF08070 DTHCT, PF02518 HATPase_c, PF01751 Toprim, PF16898 TOPRIM_C
InterPro: DNA_Topoisomerase_II, DTHCT, HATPase_C_sf, HATPase_dom, Ribosomal_Su5_D2-typ_SF, Ribsml_uS5_D2-typ_fold_subgr, Topo_IIA, Topo_IIA-like_dom_sf, Topo_IIA_A/C_ab, Topo_IIA_A_a_sf, Topo_IIA_B_C, Topo_IIA_bsu_dom2, Topo_IIA_dom_A, TopoII_euk, TopoIIA_CS, TOPRIM_C, TOPRIM_dom, TOPRIM_TopoII
Functional cluster: Central Metabolic Enzymes (KARI/Glycolysis)

Experimental structures · PDB · 20

3QX3 X-ray 2.16A
4G0U X-ray 2.70A
4G0V X-ray 2.55A
4G0W X-ray 2.70A
4J3N X-ray 2.30A
5GWI X-ray 2.74A
5GWJ X-ray 2.57A
5ZAD X-ray 2.54A
5ZEN X-ray 2.75A
5ZQF X-ray 3.87A
5ZRF X-ray 2.30A
7QFN X-ray 2.62A
… and 8 more

A predicted model is available from AlphaFold.

Gene Ontology · 20

Disease associations

B-cell immunodeficiency, distal limb anomalies, and urogenital malformations MONDO:0012243

Drugs targeting this protein · 10

DEXRAZOXANE HYDROCHLORIDE inhibitor
DEXRAZOXANE inhibitor
BERUBICIN HYDROCHLORIDE inhibitor
BECATECARIN inhibitor
PAZUFLOXACIN inhibitor
C-1311 inhibitor
AMSACRINE inhibitor
ETOPOSIDE inhibitor
TENIPOSIDE inhibitor
VOSAROXIN inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

DNA topoisomerase 2-alpha 6 shared papers
DNA topoisomerase 2-beta 1 shared papers
Large tegument protein deneddylase 1 shared papers
Phospholipid scramblase 1 1 shared papers

Literature · 37 cited papers

The Epstein-Barr virus deubiquitinating enzyme BPLF1 regulates the activity of topoisomerase II during productive infection. PLoS Pathog. · 2021
Inherited TOP2B Mutation: Possible Confirmation of Mutational Hotspots in the TOPRIM Domain. J. Clin. Immunol. · 2021
Topoisomerase 2beta mutation impairs early B-cell development. Blood · 2020
A de novo TOP2B variant associated with global developmental delay and autism spectrum disorder. Mol. Genet. Genomic Med. · 2020
Mutations in topoisomerase IIbeta result in a B cell immunodeficiency. Nat. Commun. · 2019
Global developmental delay and intellectual disability associated with a de novo TOP2B mutation. Clin. Chim. Acta · 2017
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
SUMO-2 orchestrates chromatin modifiers in response to DNA damage. Cell Rep. · 2015
System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. Mol. Cell. Proteomics · 2015
Uncovering global SUMOylation signaling networks in a site-specific manner. Nat. Struct. Mol. Biol. · 2014
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
… and 25 more in the literature graph

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