Cytochrome b

Function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.

Classification

Family (Pfam)

PF00032 Cytochrom_B_C, PF00033 Cytochrome_B

InterPro

Cyt_b/b6_C, Cyt_b/b6_C_sf, Cyt_b/b6_N, Cytb/b6-like_sf, Cytochrome_b_N_euk/bac, Di-haem_cyt_TM

Functional cluster

Cytochrome b & NADH Dehydrogenase Subunits

Gene Ontology · 5

• GO:0005743 mitochondrial inner membrane
• GO:0046872 metal ion binding
• GO:0016491 oxidoreductase activity
• GO:0008121 quinol-cytochrome-c reductase activity
• GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c

Drugs targeting this protein · 1

• ATOVAQUONE inhibitor

Related proteins · sequence + function similarity

• Cytochrome b 0.99
• Cytochrome b 0.98
• Cytochrome b 0.98
• Cytochrome b 0.93
• Cytochrome b 0.92
• Cytochrome b 0.91
• Cytochrome b 0.91
• Cytochrome b 0.91
• Cytochrome b 0.91
• Cytochrome b 0.90
• Cytochrome b 0.90
• Cytochrome b 0.90

Co-cited proteins · studied together in the literature

• Cytochrome c oxidase subunit 1 2 shared papers
• Cytochrome b 1 shared papers

Literature · 3 cited papers

• Structural features of Plasmodium cytochrome b that may underlie susceptibility to 8-aminoquinolines and hydroxynaphthoquinones. Mol. Biochem. Parasitol. · 1993
• Molecular cloning and partial sequence of a 5.8 kilobase pair repetitive DNA from Plasmodium falciparum. Mol. Biochem. Parasitol. · 1988
• Homologies between the contiguous and fragmented rRNAs of the two Plasmodium falciparum extrachromosomal DNAs are limited to core sequences. Nucleic Acids Res. · 1992