Neurogenic locus notch homolog protein 1

UniProt Q01705 Organism Mus musculus Gene Motch, Notch1

Also known as: Motch, Notch1

Function

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).

Classification

Family (Pfam): PF00023 Ank, PF12796 Ank_2, PF00008 EGF, PF07645 EGF_CA, PF12661 hEGF, PF06816 NOD, PF07684 NODP, PF00066 Notch
InterPro: Ankyrin_rpt, Ankyrin_rpt-contain_sf, EGF, EGF-like_Ca-bd_dom, EGF-like_CS, EGF-type_Asp/Asn_hydroxyl_site, EGF_Ca-bd_CS, Growth_fac_rcpt_cys_sf, Notch, Notch-like_dom_sf, Notch/Slit_guidance, NOTCH1_EGF-like, Notch_1, Notch_C, Notch_dom, Notch_NOD_dom, Notch_NODP_dom
Functional cluster: Venom Serine Proteases & Phospholipase A2

Experimental structures · PDB · 12

1YMP X-ray 2.20A
2QC9 X-ray 2.35A
2RQZ NMR
2RR0 NMR
2RR2 NMR
3P3N X-ray 2.40A
3P3P X-ray 2.60A
5KY0 X-ray 1.53A
5KY4 X-ray 1.47A
5KY8 X-ray 1.65A
5KY9 X-ray 1.83A
7ABV X-ray 2.06A

A predicted model is available from AlphaFold.

Gene Ontology · 214

Neighborhood · nearest proteins

Nearest neighbours of Neurogenic locus notch homolog protein 1: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Neurogenic locus notch homolog protein 2 6 shared papers
Delta and Notch-like epidermal growth factor-related receptor 1 shared papers
Thrombospondin-4 1 shared papers
Neurogenic locus notch homolog protein 3 5 shared papers
Mastermind-like protein 1 2 shared papers
Neurogenic locus notch homolog protein 4 3 shared papers
Zinc finger protein 64 1 shared papers
Zinc finger protein 64 1 shared papers
Inactive tyrosine-protein kinase PRAG1 1 shared papers
Disintegrin and metalloproteinase domain-containing protein 17 1 shared papers
Neurogenic locus notch homolog protein 1 7 shared papers
E3 ubiquitin-protein ligase DTX3 1 shared papers

Literature · 39 cited papers

Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling. Proc. Natl. Acad. Sci. U.S.A. · 2018
Consequences of MEGF10 deficiency on myoblast function and Notch1 interactions. Hum. Mol. Genet. · 2017
Deciphering the fringe-mediated notch code: identification of activating and inhibiting sites allowing discrimination between ligands. Dev. Cell · 2017
NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis. Cancer Res. · 2014
Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals. J. Cell Sci. · 2013
Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. Nature · 2013
BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets. Nat. Neurosci. · 2012
The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation. J. Biol. Chem. · 2012
O-glucose trisaccharide is present at high but variable stoichiometry at multiple sites on mouse Notch1. J. Biol. Chem. · 2011
The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway. J. Biol. Chem. · 2011
A tissue-specific atlas of mouse protein phosphorylation and expression. Cell · 2010
Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol. · 2009
… and 27 more in the literature graph

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