Alanine racemase

Function

Catalyzes the interconversion of L-alanine and D-alanine. D-alanine plays a key role in peptidoglycan cross-linking.

Classification

Family (Pfam)

PF00842 Ala_racemase_C, PF01168 Ala_racemase_N

InterPro

Ala_racemase, Ala_racemase/Decarboxylase_C, Ala_racemase_C, Ala_racemase_N, Ala_racemase_pyridoxalP-BS, PLP-binding_barrel

Functional cluster

Acyltransferases & Methyltransferases

Experimental structures · PDB · 4

• 1XFC X-ray 1.90A
• 6SCZ X-ray 1.57A
• 8AHW X-ray 1.58A
• 8B8H X-ray 1.78A

A predicted model is available from AlphaFold.

Gene Ontology · 5

• GO:0005829 cytosol
• GO:0008784 alanine racemase activity
• GO:0030170 pyridoxal phosphate binding
• GO:0030632 D-alanine biosynthetic process
• GO:0009252 peptidoglycan biosynthetic process

Drugs targeting this protein · 1

• CYCLOSERINE inhibitor

Related proteins · sequence + function similarity

• Alanine racemase 1.00
• Alanine racemase 1.00
• Alanine racemase 0.97
• Alanine racemase 0.97
• Alanine racemase 0.96
• Alanine racemase 0.96
• Alanine racemase 0.92
• Alanine racemase 0.92
• Alanine racemase 0.90
• Alanine racemase 0.90
• Alanine racemase 0.89
• Alanine racemase 0.89

Co-cited proteins · studied together in the literature

• Alanine racemase 1 shared papers

Literature · 4 cited papers

• Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
• The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site. Biochemistry · 2005
• Characterization of the alanine racemases from two Mycobacteria. FEMS Microbiol. Lett. · 2001
• Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998