ATP synthase subunit a

Function

Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.

Classification

Family (Pfam)

PF00119 ATP-synt_A

InterPro

ATP_syn_F0_a_bact/chloroplast, ATP_synth_F0_asu, ATP_synth_F0_asu_AS, F0_ATP_A_sf

Functional cluster

Respiratory Chain & ATP Synthase Subunits

Experimental structures · PDB · 6

• 8J0S EM 2.58A
• 8J0T EM 2.80A
• 8J57 EM 2.85A
• 8J58 EM 3.15A
• 8JR0 EM 2.80A
• 8JR1 EM 3.17A

A predicted model is available from AlphaFold.

Gene Ontology · 4

• GO:0005886 plasma membrane
• GO:0045259 proton-transporting ATP synthase complex
• GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
• GO:0042777 proton motive force-driven plasma membrane ATP synthesis

Drugs targeting this protein · 1

• BEDAQUILINE FUMARATE inhibitor

Related proteins · sequence + function similarity

• ATP synthase subunit a 1.00
• ATP synthase subunit a 0.99
• ATP synthase subunit a 0.99
• ATP synthase subunit a 0.98
• ATP synthase subunit a 0.93
• ATP synthase subunit a 0.93
• ATP synthase subunit a 0.93
• ATP synthase subunit a 0.93
• ATP synthase subunit a 0.92
• ATP synthase subunit a 0.92
• ATP synthase subunit a 0.92
• ATP synthase subunit a 0.92

Literature · 3 cited papers

• Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
• targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. BMC Syst. Biol. · 2008
• Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998