ATP synthase epsilon chain

Function

Produces ATP from ADP in the presence of a proton gradient across the membrane.

Classification

Family (Pfam)

PF02823 ATP-synt_DE_N

InterPro

ATP_synth_F1_dsu/esu, ATP_synth_F1_dsu/esu_N, ATPsynth_dsu/esu_N

Functional cluster

Ribosomal Proteins & Trigger Factor

Experimental structures · PDB · 5

• 2LX5 NMR
• 5YIO NMR
• 8J0S EM 2.58A
• 8J0T EM 2.80A
• 8JR0 EM 2.80A

A predicted model is available from AlphaFold.

Gene Ontology · 6

• GO:0009274 peptidoglycan-based cell wall
• GO:0005886 plasma membrane
• GO:0045259 proton-transporting ATP synthase complex
• GO:0005524 ATP binding
• GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
• GO:0015986 proton motive force-driven ATP synthesis

Drugs targeting this protein · 1

• BEDAQUILINE FUMARATE inhibitor

Related proteins · sequence + function similarity

• ATP synthase epsilon chain 1.00
• ATP synthase epsilon chain 1.00
• ATP synthase epsilon chain 1.00
• ATP synthase epsilon chain 1.00
• ATP synthase epsilon chain 0.98
• ATP synthase epsilon chain 0.97
• ATP synthase epsilon chain 0.97
• ATP synthase epsilon chain 0.97
• ATP synthase epsilon chain 0.97
• ATP synthase epsilon chain 0.97
• ATP synthase epsilon chain 0.96
• ATP synthase epsilon chain 0.96

Literature · 4 cited papers

• Deep N-terminomics of Mycobacterium tuberculosis H37Rv extensively correct annotated encoding genes. Genomics · 2022
• Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
• targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. BMC Syst. Biol. · 2008
• Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998