ATP synthase subunit alpha

Function

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

Classification

Family (Pfam)

PF00006 ATP-synt_ab, PF00306 ATP-synt_ab_C, PF02874 ATP-synt_ab_N

InterPro

ATP_synth_asu-like_sf, ATP_synth_asu_C, ATP_synth_asu_C_sf, ATP_synth_F1_a_nt-bd_dom, ATP_synth_F1_asu, ATPase_a/bsu_AS, ATPase_F1/V1/A1_a/bsu_N, ATPase_F1/V1/A1_a/bsu_N_sf, ATPase_F1/V1/A1_a/bsu_nucl-bd, P-loop_NTPase

Functional cluster

F/V-Type ATP Synthases & RecA/SecA ATPases

Experimental structures · PDB · 3

• 8J0S EM 2.58A
• 8J0T EM 2.80A
• 8JR0 EM 2.80A

A predicted model is available from AlphaFold.

Gene Ontology · 7

• GO:0009274 peptidoglycan-based cell wall
• GO:0005886 plasma membrane
• GO:0045259 proton-transporting ATP synthase complex
• GO:0043531 ADP binding
• GO:0005524 ATP binding
• GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
• GO:0015986 proton motive force-driven ATP synthesis

Drugs targeting this protein · 1

• BEDAQUILINE FUMARATE inhibitor

Related proteins · sequence + function similarity

• ATP synthase subunit alpha 1.00
• ATP synthase subunit alpha 1.00
• ATP synthase subunit alpha 1.00
• ATP synthase subunit alpha 1.00
• ATP synthase subunit alpha 0.99
• ATP synthase subunit alpha 0.99
• ATP synthase subunit alpha 0.98
• ATP synthase subunit alpha 0.98
• ATP synthase subunit alpha 0.97
• ATP synthase subunit alpha 0.97
• ATP synthase subunit alpha 0.97
• ATP synthase subunit alpha 0.97

Literature · 3 cited papers

• Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
• Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis. PLoS ONE · 2010
• Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998